Evolved for Hip Arthritis

AP Monk, George Grammatopoulos, Minsi Chen, CLM Gibbons, David Beard, DW Murray, HS Gill

Research output: Contribution to journalMeeting Abstractpeer-review


Osteoarthritis (OA) of the hip is an important cause of pain and morbidity. The mechanisms and pathogenesis of OA'sdevelopment remain unknown. Minor acetabular dysplasia and subtle variations in proximal femoral morphology are increasingly being recognized as factors that potentially compromise the joint biomechanically and lead to OA. Previous studies have shown that risk of hip OA increased as the femoral head to femoral neck ratio (HNR) decreased. Previous work has described the evolutionary change in inferior femoral neck trabecular density and geometry associated with upright stance, but no study has highlighted the evolutionary change in HNR. The aim of this study was to examine evolutionary evidence that the hominin bipedal stance has lead to alterations in HNR that would predispose humans to hip OA.
Original languageEnglish
Pages (from-to)263
Number of pages1
JournalOrthopaedic Proceedings
Volume94 B
Issue numberSupplement XXXVII
Publication statusPublished - Sep 2012
Externally publishedYes


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