Evolved for Hip Arthritis

AP Monk, George Grammatopoulos, Minsi Chen, CLM Gibbons, David Beard, DW Murray, HS Gill

Research output: Contribution to journalMeeting Abstract

Abstract

Osteoarthritis (OA) of the hip is an important cause of pain and morbidity. The mechanisms and pathogenesis of OA'sdevelopment remain unknown. Minor acetabular dysplasia and subtle variations in proximal femoral morphology are increasingly being recognized as factors that potentially compromise the joint biomechanically and lead to OA. Previous studies have shown that risk of hip OA increased as the femoral head to femoral neck ratio (HNR) decreased. Previous work has described the evolutionary change in inferior femoral neck trabecular density and geometry associated with upright stance, but no study has highlighted the evolutionary change in HNR. The aim of this study was to examine evolutionary evidence that the hominin bipedal stance has lead to alterations in HNR that would predispose humans to hip OA.
Original languageEnglish
Pages (from-to)263
Number of pages1
JournalOrthopaedic Proceedings
Volume94 B
Issue numberSupplement XXXVII
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

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Hip Osteoarthritis
Arthritis
Hip
Femur Neck
Thigh
Osteoarthritis
Hominidae
Joints
Morbidity
Pain

Cite this

Monk, AP., Grammatopoulos, G., Chen, M., Gibbons, CLM., Beard, D., Murray, DW., & Gill, HS. (2012). Evolved for Hip Arthritis. Orthopaedic Proceedings, 94 B(Supplement XXXVII), 263. https://doi.org/10.1302/1358-992X.94BSUPP_XXXVII.EFORT2011-263
Monk, AP ; Grammatopoulos, George ; Chen, Minsi ; Gibbons, CLM ; Beard, David ; Murray, DW ; Gill, HS. / Evolved for Hip Arthritis. In: Orthopaedic Proceedings. 2012 ; Vol. 94 B, No. Supplement XXXVII. pp. 263.
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abstract = "Osteoarthritis (OA) of the hip is an important cause of pain and morbidity. The mechanisms and pathogenesis of OA'sdevelopment remain unknown. Minor acetabular dysplasia and subtle variations in proximal femoral morphology are increasingly being recognized as factors that potentially compromise the joint biomechanically and lead to OA. Previous studies have shown that risk of hip OA increased as the femoral head to femoral neck ratio (HNR) decreased. Previous work has described the evolutionary change in inferior femoral neck trabecular density and geometry associated with upright stance, but no study has highlighted the evolutionary change in HNR. The aim of this study was to examine evolutionary evidence that the hominin bipedal stance has lead to alterations in HNR that would predispose humans to hip OA.",
author = "AP Monk and George Grammatopoulos and Minsi Chen and CLM Gibbons and David Beard and DW Murray and HS Gill",
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Monk, AP, Grammatopoulos, G, Chen, M, Gibbons, CLM, Beard, D, Murray, DW & Gill, HS 2012, 'Evolved for Hip Arthritis', Orthopaedic Proceedings, vol. 94 B, no. Supplement XXXVII, pp. 263. https://doi.org/10.1302/1358-992X.94BSUPP_XXXVII.EFORT2011-263

Evolved for Hip Arthritis. / Monk, AP; Grammatopoulos, George; Chen, Minsi; Gibbons, CLM; Beard, David; Murray, DW; Gill, HS.

In: Orthopaedic Proceedings, Vol. 94 B, No. Supplement XXXVII, 09.2012, p. 263.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Evolved for Hip Arthritis

AU - Monk, AP

AU - Grammatopoulos, George

AU - Chen, Minsi

AU - Gibbons, CLM

AU - Beard, David

AU - Murray, DW

AU - Gill, HS

PY - 2012/9

Y1 - 2012/9

N2 - Osteoarthritis (OA) of the hip is an important cause of pain and morbidity. The mechanisms and pathogenesis of OA'sdevelopment remain unknown. Minor acetabular dysplasia and subtle variations in proximal femoral morphology are increasingly being recognized as factors that potentially compromise the joint biomechanically and lead to OA. Previous studies have shown that risk of hip OA increased as the femoral head to femoral neck ratio (HNR) decreased. Previous work has described the evolutionary change in inferior femoral neck trabecular density and geometry associated with upright stance, but no study has highlighted the evolutionary change in HNR. The aim of this study was to examine evolutionary evidence that the hominin bipedal stance has lead to alterations in HNR that would predispose humans to hip OA.

AB - Osteoarthritis (OA) of the hip is an important cause of pain and morbidity. The mechanisms and pathogenesis of OA'sdevelopment remain unknown. Minor acetabular dysplasia and subtle variations in proximal femoral morphology are increasingly being recognized as factors that potentially compromise the joint biomechanically and lead to OA. Previous studies have shown that risk of hip OA increased as the femoral head to femoral neck ratio (HNR) decreased. Previous work has described the evolutionary change in inferior femoral neck trabecular density and geometry associated with upright stance, but no study has highlighted the evolutionary change in HNR. The aim of this study was to examine evolutionary evidence that the hominin bipedal stance has lead to alterations in HNR that would predispose humans to hip OA.

UR - https://online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.94BSUPP_XXXVII.EFORT2011-263

U2 - 10.1302/1358-992X.94BSUPP_XXXVII.EFORT2011-263

DO - 10.1302/1358-992X.94BSUPP_XXXVII.EFORT2011-263

M3 - Meeting Abstract

VL - 94 B

SP - 263

JO - Orthopaedic Proceedings

JF - Orthopaedic Proceedings

SN - 2049-4416

IS - Supplement XXXVII

ER -

Monk AP, Grammatopoulos G, Chen M, Gibbons CLM, Beard D, Murray DW et al. Evolved for Hip Arthritis. Orthopaedic Proceedings. 2012 Sep;94 B(Supplement XXXVII):263. https://doi.org/10.1302/1358-992X.94BSUPP_XXXVII.EFORT2011-263