Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A. Parkinson; Fraser J. Scott; Colin J. Suckling; Gail Wilson

doi:10.1039/c3md00071k

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A. Parkinson, Fraser J. Scott, Colin J. Suckling, Gail Wilson

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

Original language	English
Pages (from-to)	1105-1108
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	7
DOIs	https://doi.org/10.1039/c3md00071k
Publication status	Published - 1 Jan 2013
Externally published	Yes

Access to Document

10.1039/c3md00071k

http://xlink.rsc.org/?DOI=c3md00071k

Cite this

@article{fc3f4254b4b544d48c060efaf4456942,

title = "Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences",

abstract = "An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.",

author = "Parkinson, {John A.} and Scott, {Fraser J.} and Suckling, {Colin J.} and Gail Wilson",

year = "2013",

month = jan,

day = "1",

doi = "10.1039/c3md00071k",

language = "English",

volume = "4",

pages = "1105--1108",

journal = "RSC Medicinal Chemistry",

issn = "2632-8682",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

AU - Parkinson, John A.

AU - Scott, Fraser J.

AU - Suckling, Colin J.

AU - Wilson, Gail

PY - 2013/1/1

Y1 - 2013/1/1

N2 - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

AB - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

U2 - 10.1039/c3md00071k

DO - 10.1039/c3md00071k

M3 - Article

VL - 4

SP - 1105

EP - 1108

JO - RSC Medicinal Chemistry

JF - RSC Medicinal Chemistry

SN - 2632-8682

IS - 7

ER -