Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A. Parkinson; Fraser J. Scott; Colin J. Suckling; Gail Wilson

doi:10.1039/c3md00071k

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A. Parkinson, Fraser J. Scott, Colin J. Suckling, Gail Wilson

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

Original language	English
Pages (from-to)	1105-1108
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	7
DOIs	https://doi.org/10.1039/c3md00071k
Publication status	Published - 1 Jan 2013
Externally published	Yes

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title = "Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences",

abstract = "An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.",

author = "Parkinson, {John A.} and Scott, {Fraser J.} and Suckling, {Colin J.} and Gail Wilson",

year = "2013",

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doi = "10.1039/c3md00071k",

language = "English",

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AU - Scott, Fraser J.

AU - Suckling, Colin J.

AU - Wilson, Gail

PY - 2013/1/1

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N2 - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

AB - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

U2 - 10.1039/c3md00071k

DO - 10.1039/c3md00071k

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SN - 2040-2503

VL - 4

SP - 1105

EP - 1108

JO - MedChemComm

JF - MedChemComm

IS - 7

ER -

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

Abstract

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