Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A. Parkinson; Fraser J. Scott; Colin J. Suckling; Gail Wilson

doi:10.1039/c3md00071k

Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

John A. Parkinson, Fraser J. Scott, Colin J. Suckling, Gail Wilson

University of Strathclyde

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

Original language	English
Pages (from-to)	1105-1108
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	7
DOIs	https://doi.org/10.1039/c3md00071k
Publication status	Published - 1 Jan 2013
Externally published	Yes

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title = "Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences",

abstract = "An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.",

author = "Parkinson, \{John A.\} and Scott, \{Fraser J.\} and Suckling, \{Colin J.\} and Gail Wilson",

year = "2013",

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doi = "10.1039/c3md00071k",

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AU - Scott, Fraser J.

AU - Suckling, Colin J.

AU - Wilson, Gail

PY - 2013/1/1

Y1 - 2013/1/1

N2 - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

AB - An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

U2 - 10.1039/c3md00071k

DO - 10.1039/c3md00071k

M3 - Article

SN - 2040-2503

VL - 4

SP - 1105

EP - 1108

JO - MedChemComm

JF - MedChemComm

IS - 7

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Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

Abstract

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