Expedient synthesis of highly substituted 3,4-dihydro-1,2-oxathiine 2,2-dioxides and 1,2-oxathiine 2,2-dioxides: Revisiting sulfene additions to enaminoketones

Stuart Aiken, Kelechi Anozie, Orlando De Azevedo, Lewis Cowan, Ross Edgar, Christopher Gabbutt, Bernard Heron, Pippa Lawrence, Abby Mills, Craig Rice, Mike Urquhart, Dimitrios Zonidis

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Diversely substituted 1,2-oxathiine 2,2-dioxides, including 3,5,6-triaryl-, 3,6-diaryl-, 3,5-diaryl-, 5,6-diaryl- and selected fused heterocyclic analogues, have been efficiently obtained by the application of a mild Cope elimination of a 4-amino moiety from the requisite 4-amino-3,4-dihydro-1,2-oxathiine 2,2-dioxides, which themselves were readily obtained by the addition of sulfenes to enaminoketones.
Original languageEnglish
Pages (from-to)9585-9604
Number of pages20
JournalOrganic and Biomolecular Chemistry
Issue number44
Early online date31 Oct 2019
Publication statusPublished - Nov 2019


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