Abstract
An unstructured kinetic model for the growth of Actinobacillus succinogenes on glycerol as the only carbon source is proposed in this study. The model describes cell growth considering both substrate and product inhibition. and its parameters are estimated by fitting the model predictions to experimental data. Substrate consumption and product formation rates are described by the Luedeking-Piret model. The main product of the process is succinic acid while by-products like acetate, formate and ethanol have very low concentrations. The main environmental factors that affect the bioprocess were examined and optimum conditions in terms of yield, final succinic acid concentration and productivity were evaluated by a factorial experimental procedure. The examined parameters were the supply of CO2, the pH level and the redox balance. Experiments using different initial glycerol concentrations at the "optimum" environmental conditions were carried out and simulation studies were performed using the proposed model.
Original language | English |
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Title of host publication | AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings |
Publication status | Published - 1 Dec 2008 |
Externally published | Yes |
Event | American Institute of Chemical Engineers Annual Meeting - Philadelphia, United States Duration: 16 Nov 2008 → 21 Nov 2008 Conference number: 100 https://www.aiche.org/conferences/aiche-annual-meeting/2008 (Link to Conference Information) |
Conference
Conference | American Institute of Chemical Engineers Annual Meeting |
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Abbreviated title | AIChE |
Country/Territory | United States |
City | Philadelphia |
Period | 16/11/08 → 21/11/08 |
Internet address |
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