Experimental validation of an extended Jones matrix calculus model to study the 3D structural orientation of the collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography

Deepa K. Kasaragod, Zenghai Lu, James Jacobs, Stephen J. Matcher

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

We report results to verify a theoretical framework to analyze the 3D depth-wise structural organization of collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography. Apparent birefringence data obtained from multi-angle measurements using a time domain polarization-sensitive optical coherence tomography system has been compared with simulated data based on the extended Jones matrix calculus. Experimental data has been shown to agree with the lamellar model previously proposed for the cartilage microstructure based on scanning electron microscopy data. This tool could have potential application in mapping the collagen structural orientation information of cartilage non-invasively during arthroscopy.

Original languageEnglish
Pages (from-to)378-387
Number of pages10
JournalBiomedical Optics Express
Volume3
Issue number3
Early online date31 Jan 2012
DOIs
Publication statusPublished - 1 Mar 2012
Externally publishedYes

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