Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles

Roy P. Lester, Travis Bham, Thomas W. Bousfield, William Lewis, Jason E. Camp

Research output: Contribution to journalArticle

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Abstract

The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2′-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material.
Original languageEnglish
Pages (from-to)12472-12477
Number of pages6
JournalJournal of Organic Chemistry
Volume81
Issue number24
Early online date6 Dec 2016
DOIs
Publication statusPublished - Dec 2016

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