Exploring the role of the posterior middle temporal gyrus in semantic cognition

Integration of anterior temporal lobe with executive processes

James Davey, Hannah E. Thompson, Glyn Hallam, Theodoros Karapanagiotidis, Charlotte Murphy, Irene De Caso, Katya Krieger-Redwood, Boris C. Bernhardt, Jonathan Smallwood, Elizabeth Jefferies

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Making sense of the world around us depends upon selectively retrieving information relevant to our current goal or context. However, it is unclear whether selective semantic retrieval relies exclusively on general control mechanisms recruited in demanding non-semantic tasks, or instead on systems specialised for the control of meaning. One hypothesis is that the left posterior middle temporal gyrus (pMTG) is important in the controlled retrieval of semantic (not non-semantic) information; however this view remains controversial since a parallel literature links this site to event and relational semantics. In a functional neuroimaging study, we demonstrated that an area of pMTG implicated in semantic control by a recent meta-analysis was activated in a conjunction of (i) semantic association over size judgements and (ii) action over colour feature matching. Under these circumstances the same region showed functional coupling with the inferior frontal gyrus - another crucial site for semantic control. Structural and functional connectivity analyses demonstrated that this site is at the nexus of networks recruited in automatic semantic processing (the default mode network) and executively demanding tasks (the multiple-demand network). Moreover, in both task and task-free contexts, pMTG exhibited functional properties that were more similar to ventral parts of inferior frontal cortex, implicated in controlled semantic retrieval, than more dorsal inferior frontal sulcus, implicated in domain-general control. Finally, the pMTG region was functionally correlated at rest with other regions implicated in control-demanding semantic tasks, including inferior frontal gyrus and intraparietal sulcus. We suggest that pMTG may play a crucial role within a large-scale network that allows the integration of automatic retrieval in the default mode network with executively-demanding goal-oriented cognition, and that this could support our ability to understand actions and non-dominant semantic associations, allowing semantic retrieval to be 'shaped' to suit a task or context.

Original languageEnglish
Pages (from-to)165-177
Number of pages13
JournalNeuroImage
Volume137
Early online date25 May 2016
DOIs
Publication statusPublished - 15 Aug 2016
Externally publishedYes

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Temporal Lobe
Semantics
Cognition
Prefrontal Cortex
Parietal Lobe
Functional Neuroimaging
Aptitude
Frontal Lobe
Meta-Analysis
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Cite this

Davey, James ; Thompson, Hannah E. ; Hallam, Glyn ; Karapanagiotidis, Theodoros ; Murphy, Charlotte ; De Caso, Irene ; Krieger-Redwood, Katya ; Bernhardt, Boris C. ; Smallwood, Jonathan ; Jefferies, Elizabeth. / Exploring the role of the posterior middle temporal gyrus in semantic cognition : Integration of anterior temporal lobe with executive processes. In: NeuroImage. 2016 ; Vol. 137. pp. 165-177.
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Davey, J, Thompson, HE, Hallam, G, Karapanagiotidis, T, Murphy, C, De Caso, I, Krieger-Redwood, K, Bernhardt, BC, Smallwood, J & Jefferies, E 2016, 'Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes', NeuroImage, vol. 137, pp. 165-177. https://doi.org/10.1016/j.neuroimage.2016.05.051

Exploring the role of the posterior middle temporal gyrus in semantic cognition : Integration of anterior temporal lobe with executive processes. / Davey, James; Thompson, Hannah E.; Hallam, Glyn; Karapanagiotidis, Theodoros; Murphy, Charlotte; De Caso, Irene; Krieger-Redwood, Katya; Bernhardt, Boris C.; Smallwood, Jonathan; Jefferies, Elizabeth.

In: NeuroImage, Vol. 137, 15.08.2016, p. 165-177.

Research output: Contribution to journalArticle

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T2 - Integration of anterior temporal lobe with executive processes

AU - Davey, James

AU - Thompson, Hannah E.

AU - Hallam, Glyn

AU - Karapanagiotidis, Theodoros

AU - Murphy, Charlotte

AU - De Caso, Irene

AU - Krieger-Redwood, Katya

AU - Bernhardt, Boris C.

AU - Smallwood, Jonathan

AU - Jefferies, Elizabeth

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