Expression of HIF-1α and Glut-1 in human bladder cancer

Victor Palit, R. M. Phillips, R. Puri, T. Shah, M. C. Bibby

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52 Citations (Scopus)

Abstract

HIF-1 is a heterodimer consisting of the HIF-1α and HIF-1β subunits, and HIF-1α is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1α upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody specific for HIF-1α indicate that the overexpression of HIF-1α occurs in the most common forms of human cancer, including bladder cancer. The expression of Glut-1 in human bladder cancer is associated with poor prognosis and a low survival rate. To our knowledge this is the first study to compare the expression of both HIF-1α and Glut-1 with clinico-pathological characteristics in superficial and invasive human bladder cancer (all invasive bladder cancer patients received radical radiotherapy). The Kaplan-Meier survival analysis curve shows a significant association of HIF-1α expression with recurrence and survival in superficial bladder cancer and shows a significant association of Glut-1 with survival in invasive bladder cancer [chi2 (4)=10.52; Pr > chi2=0.0012].

Original languageEnglish
Pages (from-to)909-913
Number of pages5
JournalOncology Reports
Volume14
Issue number4
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

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