Extracellular Interactome of the FGF Receptor-Ligand System: Complexities and the Relative Simplicity of the Worm

Urszula M. Polanska, David G. Fernig, Tarja Kinnunen

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate a multitude of biological functions in embryonic development and in adult. A major question is how does one family of growth factors and their receptors control such a variety of functions? Classically, specificity was thought to be imparted by alternative splicing of the FGFRs, resulting in isoforms that bind specifically to a subset of the FGFs, and by different saccharide sequences in the heparan sulfate proteoglycan (HSPG) co-receptor. A growing number of noncanonical co-receptors such as integrins and neural cell adhesion molecule (NCAM) are now recognized as imparting additional complexity to classic FGFR signaling. This review will discuss the noncanonical FGFR ligands and speculate on the possibility that they provide additional and alternative means to determining the functional specificity of FGFR signaling. We will also discuss how invertebrate models such as C. elegans may advance our understanding of noncanonical FGFR signaling.

Original languageEnglish
Pages (from-to)277-293
Number of pages17
JournalDevelopmental Dynamics
Volume238
Issue number2
Early online date22 Jan 2009
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

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