TY - JOUR
T1 - Factors associated with poor CD4 and viral load outcomes in patients with HIV/AIDS
AU - Syed, Imran Ahmed
AU - Sulaiman, Syed Azhar Syed
AU - Hassali, Mohammad Azmi
AU - Syed, Shahzad Hasan
AU - Shan, Lau Hui
AU - Lee, Christopher K.C.
PY - 2016/5
Y1 - 2016/5
N2 - Suboptimal viral suppression and CD4 response to antiretroviral treatment (HAART) is known to cause poor outcomes with the increase cost of treatment. We aimed to assess factors associated with such control among HIV/AIDS patients in Malaysia. Four hundred and six HIV/AIDS patients, using Antiretroviral Therapy (ART) for at least the past three months, treated as outpatients at medication therapy adherence clinics (MTAC) were recruited. CD4 cell counts, viral load readings along with co-variants such as socio-demographic factors, adverse drug reactions, comorbidities, and medication record were obtained. Statistical Package for Social Sciences (SPSS®) version 18 and STATA IC® version 12 were used for data analysis. CD4 counts were found highest among those within the age category 41-50 years (390.43±272.28), female (402.64±276.14), other ethnicities (400.20±278.04), and participants with no formal education (414.87±290.90). Patients experiencing adverse effects had a 2.28 (95%CI:1.25-4.18) fold greater risk of poor CD4 control, while patients with comorbidities had 2.46 (95%CI:1.02-5.91) fold greater risk of mild viral suppression. Adverse drug reactions, co-morbidities were found to be significantly associated with poor immunological and virological outcomes in HIV/AIDS patients. However, a comprehensive evaluation is needed to better understand other confounders.
AB - Suboptimal viral suppression and CD4 response to antiretroviral treatment (HAART) is known to cause poor outcomes with the increase cost of treatment. We aimed to assess factors associated with such control among HIV/AIDS patients in Malaysia. Four hundred and six HIV/AIDS patients, using Antiretroviral Therapy (ART) for at least the past three months, treated as outpatients at medication therapy adherence clinics (MTAC) were recruited. CD4 cell counts, viral load readings along with co-variants such as socio-demographic factors, adverse drug reactions, comorbidities, and medication record were obtained. Statistical Package for Social Sciences (SPSS®) version 18 and STATA IC® version 12 were used for data analysis. CD4 counts were found highest among those within the age category 41-50 years (390.43±272.28), female (402.64±276.14), other ethnicities (400.20±278.04), and participants with no formal education (414.87±290.90). Patients experiencing adverse effects had a 2.28 (95%CI:1.25-4.18) fold greater risk of poor CD4 control, while patients with comorbidities had 2.46 (95%CI:1.02-5.91) fold greater risk of mild viral suppression. Adverse drug reactions, co-morbidities were found to be significantly associated with poor immunological and virological outcomes in HIV/AIDS patients. However, a comprehensive evaluation is needed to better understand other confounders.
KW - Anti-retroviral therapy
KW - CD4 outcomes
KW - Factors associated
KW - HIV & AIDS
KW - Viral suppression
UR - http://www.scopus.com/inward/record.url?scp=84959377987&partnerID=8YFLogxK
UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1096-9071
U2 - 10.1002/jmv.24389
DO - 10.1002/jmv.24389
M3 - Article
C2 - 26399724
AN - SCOPUS:84959377987
VL - 88
SP - 790
EP - 797
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 5
ER -