Factors Influencing Concomitant Use of Complementary and Alternative Medicines with Warfarin

Shahzad S. Hasan, Siow R. Feng, Keivan Ahmadi, Kamarunnesa M. Ahmad, David W.K. Chong, Mudassir Anwar, Nurul Z. Badarudin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: To investigate factors influencing complementary and alternative medicines (CAM) use among patients on warfarin. 

Method: Cross-sectional study of randomly selected patients at a hospital-based anticoagulation clinic in Malaysia. A 38- item validated data collection form was used to interview patients and investigate the reasons, perceived efficacy and adverse drug events experienced. Data were also collected on potential drug interactions and the international normalised ratio (INR). 

Results: Of the 138 randomly selected patients, 76 (55%) reported using CAM - 46 (61%) used biologically based practices such as herbal products, vitamins and supplements. Monthly household income (p = 0.05, r = 0.13) and family history of CAM use (p = 0.001, r = 0.32) were significantly associated and positively correlated with CAM use. 19 patients reported adverse events with warfarin use while none reported adverse events with CAM use. 19 and 58 patients, respectively, were identified as being at risk of potential interactions between warfarin-CAM and warfarin-conventional medicines. No significant difference in the mean INR was found between CAM and non-CAM users. 

Conclusion: A large number of patients attending the anticoagulation clinic reported using CAM. Socioeconomic factors such as monthly household income, education level and family history of CAM use were significantly related with CAM use. Routine medication interviews should include questions about concomitant CAM use.

Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalJournal of Pharmacy Practice and Research
Volume40
Issue number4
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Fingerprint

Warfarin
Complementary Therapies
Medicine
Drug interactions
History of Medicine
International Normalized Ratio
Bioelectric potentials
Vitamins
Education
Interviews

Cite this

Hasan, Shahzad S. ; Feng, Siow R. ; Ahmadi, Keivan ; Ahmad, Kamarunnesa M. ; Chong, David W.K. ; Anwar, Mudassir ; Badarudin, Nurul Z. / Factors Influencing Concomitant Use of Complementary and Alternative Medicines with Warfarin. In: Journal of Pharmacy Practice and Research. 2010 ; Vol. 40, No. 4. pp. 294-299.
@article{97e9859ce5b142de89b19ff649d543c0,
title = "Factors Influencing Concomitant Use of Complementary and Alternative Medicines with Warfarin",
abstract = "Aim: To investigate factors influencing complementary and alternative medicines (CAM) use among patients on warfarin. Method: Cross-sectional study of randomly selected patients at a hospital-based anticoagulation clinic in Malaysia. A 38- item validated data collection form was used to interview patients and investigate the reasons, perceived efficacy and adverse drug events experienced. Data were also collected on potential drug interactions and the international normalised ratio (INR). Results: Of the 138 randomly selected patients, 76 (55{\%}) reported using CAM - 46 (61{\%}) used biologically based practices such as herbal products, vitamins and supplements. Monthly household income (p = 0.05, r = 0.13) and family history of CAM use (p = 0.001, r = 0.32) were significantly associated and positively correlated with CAM use. 19 patients reported adverse events with warfarin use while none reported adverse events with CAM use. 19 and 58 patients, respectively, were identified as being at risk of potential interactions between warfarin-CAM and warfarin-conventional medicines. No significant difference in the mean INR was found between CAM and non-CAM users. Conclusion: A large number of patients attending the anticoagulation clinic reported using CAM. Socioeconomic factors such as monthly household income, education level and family history of CAM use were significantly related with CAM use. Routine medication interviews should include questions about concomitant CAM use.",
author = "Hasan, {Shahzad S.} and Feng, {Siow R.} and Keivan Ahmadi and Ahmad, {Kamarunnesa M.} and Chong, {David W.K.} and Mudassir Anwar and Badarudin, {Nurul Z.}",
year = "2010",
month = "12",
doi = "10.1002/j.2055-2335.2010.tb00563.x",
language = "English",
volume = "40",
pages = "294--299",
journal = "Journal of Pharmacy Practice and Research",
issn = "1445-937X",
publisher = "Society of Hospital Pharmacists of Australia",
number = "4",

}

Factors Influencing Concomitant Use of Complementary and Alternative Medicines with Warfarin. / Hasan, Shahzad S.; Feng, Siow R.; Ahmadi, Keivan; Ahmad, Kamarunnesa M.; Chong, David W.K.; Anwar, Mudassir; Badarudin, Nurul Z.

In: Journal of Pharmacy Practice and Research, Vol. 40, No. 4, 12.2010, p. 294-299.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors Influencing Concomitant Use of Complementary and Alternative Medicines with Warfarin

AU - Hasan, Shahzad S.

AU - Feng, Siow R.

AU - Ahmadi, Keivan

AU - Ahmad, Kamarunnesa M.

AU - Chong, David W.K.

AU - Anwar, Mudassir

AU - Badarudin, Nurul Z.

PY - 2010/12

Y1 - 2010/12

N2 - Aim: To investigate factors influencing complementary and alternative medicines (CAM) use among patients on warfarin. Method: Cross-sectional study of randomly selected patients at a hospital-based anticoagulation clinic in Malaysia. A 38- item validated data collection form was used to interview patients and investigate the reasons, perceived efficacy and adverse drug events experienced. Data were also collected on potential drug interactions and the international normalised ratio (INR). Results: Of the 138 randomly selected patients, 76 (55%) reported using CAM - 46 (61%) used biologically based practices such as herbal products, vitamins and supplements. Monthly household income (p = 0.05, r = 0.13) and family history of CAM use (p = 0.001, r = 0.32) were significantly associated and positively correlated with CAM use. 19 patients reported adverse events with warfarin use while none reported adverse events with CAM use. 19 and 58 patients, respectively, were identified as being at risk of potential interactions between warfarin-CAM and warfarin-conventional medicines. No significant difference in the mean INR was found between CAM and non-CAM users. Conclusion: A large number of patients attending the anticoagulation clinic reported using CAM. Socioeconomic factors such as monthly household income, education level and family history of CAM use were significantly related with CAM use. Routine medication interviews should include questions about concomitant CAM use.

AB - Aim: To investigate factors influencing complementary and alternative medicines (CAM) use among patients on warfarin. Method: Cross-sectional study of randomly selected patients at a hospital-based anticoagulation clinic in Malaysia. A 38- item validated data collection form was used to interview patients and investigate the reasons, perceived efficacy and adverse drug events experienced. Data were also collected on potential drug interactions and the international normalised ratio (INR). Results: Of the 138 randomly selected patients, 76 (55%) reported using CAM - 46 (61%) used biologically based practices such as herbal products, vitamins and supplements. Monthly household income (p = 0.05, r = 0.13) and family history of CAM use (p = 0.001, r = 0.32) were significantly associated and positively correlated with CAM use. 19 patients reported adverse events with warfarin use while none reported adverse events with CAM use. 19 and 58 patients, respectively, were identified as being at risk of potential interactions between warfarin-CAM and warfarin-conventional medicines. No significant difference in the mean INR was found between CAM and non-CAM users. Conclusion: A large number of patients attending the anticoagulation clinic reported using CAM. Socioeconomic factors such as monthly household income, education level and family history of CAM use were significantly related with CAM use. Routine medication interviews should include questions about concomitant CAM use.

UR - http://www.scopus.com/inward/record.url?scp=78751551082&partnerID=8YFLogxK

UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2055-2335

U2 - 10.1002/j.2055-2335.2010.tb00563.x

DO - 10.1002/j.2055-2335.2010.tb00563.x

M3 - Article

VL - 40

SP - 294

EP - 299

JO - Journal of Pharmacy Practice and Research

JF - Journal of Pharmacy Practice and Research

SN - 1445-937X

IS - 4

ER -