Farming, slaving and enslavement

Histories of endosymbioses during kinetoplastid evolution

Jane Harmer, Vyacheslav Yurchenko, Anna Nenarokova, Julius Lukeš, Michael Ginger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Parasitic trypanosomatids diverged from free-living kinetoplastid ancestors several hundred million years ago. These parasites are relatively well known, due in part to several unusual cell biological and molecular traits and in part to the significance of a few – pathogenic Leishmania and Trypanosoma species – as aetiological agents of serious neglected tropical diseases. However, the majority of trypanosomatid biodiversity is represented by osmotrophic monoxenous parasites of insects. In two lineages, novymonads and strigomonads, osmotrophic lifestyles are supported by cytoplasmic endosymbionts, providing hosts with macromolecular precursors and vitamins. Here we discuss the two independent origins of endosymbiosis within trypanosomatids and subsequently different evolutionary trajectories that see entrainment vs tolerance of symbiont cell divisions cycles within those of the host. With the potential to inform on the transition to obligate parasitism in the trypanosomatids, interest in the biology and ecology of free-living, phagotrophic kinetoplastids is beginning to enjoy a renaissance. Thus, we take the opportunity to additionally consider the wider relevance of endosymbiosis during kinetoplastid evolution, including the indulged lifestyle and reductive evolution of basal kinetoplastid Perkinsela.
Original languageEnglish
Pages (from-to)1311-1323
Number of pages13
JournalParasitology
Volume145
Issue number10
Early online date13 Jun 2018
DOIs
Publication statusPublished - 1 Sep 2018

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Slavery
Trypanosomatidae
Symbiosis
Agriculture
symbiosis
Life Style
Parasites
farming systems
Neglected Diseases
Trypanosoma
Leishmania
Biodiversity
Ecology
lifestyle
Insects
Cell Cycle
parasites
etiological agents
endosymbionts
symbionts

Cite this

Harmer, Jane ; Yurchenko, Vyacheslav ; Nenarokova, Anna ; Lukeš, Julius ; Ginger, Michael. / Farming, slaving and enslavement : Histories of endosymbioses during kinetoplastid evolution. In: Parasitology. 2018 ; Vol. 145, No. 10. pp. 1311-1323.
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abstract = "Parasitic trypanosomatids diverged from free-living kinetoplastid ancestors several hundred million years ago. These parasites are relatively well known, due in part to several unusual cell biological and molecular traits and in part to the significance of a few – pathogenic Leishmania and Trypanosoma species – as aetiological agents of serious neglected tropical diseases. However, the majority of trypanosomatid biodiversity is represented by osmotrophic monoxenous parasites of insects. In two lineages, novymonads and strigomonads, osmotrophic lifestyles are supported by cytoplasmic endosymbionts, providing hosts with macromolecular precursors and vitamins. Here we discuss the two independent origins of endosymbiosis within trypanosomatids and subsequently different evolutionary trajectories that see entrainment vs tolerance of symbiont cell divisions cycles within those of the host. With the potential to inform on the transition to obligate parasitism in the trypanosomatids, interest in the biology and ecology of free-living, phagotrophic kinetoplastids is beginning to enjoy a renaissance. Thus, we take the opportunity to additionally consider the wider relevance of endosymbiosis during kinetoplastid evolution, including the indulged lifestyle and reductive evolution of basal kinetoplastid Perkinsela.",
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Farming, slaving and enslavement : Histories of endosymbioses during kinetoplastid evolution. / Harmer, Jane; Yurchenko, Vyacheslav; Nenarokova, Anna; Lukeš, Julius; Ginger, Michael.

In: Parasitology, Vol. 145, No. 10, 01.09.2018, p. 1311-1323.

Research output: Contribution to journalArticle

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