First evaluation of the serum level of anti-hepatitis b surface antigen after vaccination in Libya

A. Madour, A. Alkout, S. Vanin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The hepatitis B virus (HBV) vaccination schedule in Libya follows international recommendations (1st dose at birth, 2nd after 1 month and 3rd after 6 months). This research aimed to evaluate the long-term protection of the HBV immunization programme in Tripoli and to determine the best age to administer booster doses. Serum levels of hepatitis B surface antigen were determined in 277 randomly selected children aged 1-12 years. The response to HBV vaccine in 1-3-year-olds was 93.2%, but this declined with age and at 7-9 years after initial vaccination only 53.1% of children had protective titres (≥ 10 mIU/mL). No significant differences between males and females in antibody persistence or response to vaccine were observed. We recommend continuing the HBV vaccination programme and that a booster dose be given to 6-year-old children to ensure maximum protection during the period of school entry and beyond.

Translated title of the contributionFirst evaluation of the serum level of anti-hepatitis b surface antigen after vaccination in Libya
LanguageFrench
Pages990-994
Number of pages5
JournalEastern Mediterranean Health Journal
Volume19
Issue number12
Publication statusPublished - 2013

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Libya
Surface Antigens
Hepatitis B virus
Hepatitis
Vaccination
Serum
Immunization Programs
Hepatitis B Vaccines
Hepatitis B Surface Antigens
Appointments and Schedules
Vaccines
Parturition
Antibodies
Research

Cite this

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title = "Premi{\`e}re {\'e}valuation de la concentration s{\'e}rique de l'antig{\`e}ne de surface du virus de l'h{\'e}patite b apr{\`e}s la vaccination en Libye",
abstract = "The hepatitis B virus (HBV) vaccination schedule in Libya follows international recommendations (1st dose at birth, 2nd after 1 month and 3rd after 6 months). This research aimed to evaluate the long-term protection of the HBV immunization programme in Tripoli and to determine the best age to administer booster doses. Serum levels of hepatitis B surface antigen were determined in 277 randomly selected children aged 1-12 years. The response to HBV vaccine in 1-3-year-olds was 93.2{\%}, but this declined with age and at 7-9 years after initial vaccination only 53.1{\%} of children had protective titres (≥ 10 mIU/mL). No significant differences between males and females in antibody persistence or response to vaccine were observed. We recommend continuing the HBV vaccination programme and that a booster dose be given to 6-year-old children to ensure maximum protection during the period of school entry and beyond.",
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Première évaluation de la concentration sérique de l'antigène de surface du virus de l'hépatite b après la vaccination en Libye. / Madour, A.; Alkout, A.; Vanin, S.

In: Eastern Mediterranean Health Journal, Vol. 19, No. 12, 2013, p. 990-994.

Research output: Contribution to journalArticle

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AB - The hepatitis B virus (HBV) vaccination schedule in Libya follows international recommendations (1st dose at birth, 2nd after 1 month and 3rd after 6 months). This research aimed to evaluate the long-term protection of the HBV immunization programme in Tripoli and to determine the best age to administer booster doses. Serum levels of hepatitis B surface antigen were determined in 277 randomly selected children aged 1-12 years. The response to HBV vaccine in 1-3-year-olds was 93.2%, but this declined with age and at 7-9 years after initial vaccination only 53.1% of children had protective titres (≥ 10 mIU/mL). No significant differences between males and females in antibody persistence or response to vaccine were observed. We recommend continuing the HBV vaccination programme and that a booster dose be given to 6-year-old children to ensure maximum protection during the period of school entry and beyond.

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