Flagellum assembly and function during the Leishmania life cycle

Eva Gluenz, Michael L. Ginger, Paul G. McKean

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages.

Original languageEnglish
Pages (from-to)473-479
Number of pages7
JournalCurrent Opinion in Microbiology
Volume13
Issue number4
Early online date11 Jun 2010
DOIs
Publication statusPublished - 1 Aug 2010
Externally publishedYes

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