Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

Yeteng He , Khadija Majeed , Maimoona Maqbool , Talib Hussain, Abid Yousaf, Ikram Ullah Khan , Yasir Mehmood, Ambreen Aleem , Muhammad Sohail Arshad, Adnan Younus, Jorabar Nirwan, Muhammad Usman Ghori, Syed Rizvi, Yasser Shahzad

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease associated with severe joint pain. Herein, we report lornoxicam loaded cellulosic microsponge gel formulation with sustained anti-inflammatory effects that are required to manage arthritic pain. The microsponges were formulated using quasi emulsion-solvent diffusion method employing four different surfactant systems, namely polyvinyl alcohol (PVA), Tween80, Gelucire 48/16 and Gelucire 50/13. All the lornoxicam loaded microsponge formulations were extensively characterized with a variety of analytical tools. The optimized microsponge formulation was then converted into gel formulation. The lornoxicam loaded microsponge gel formulation had adequate viscosity and sufficient pharmaceutical properties as confirmed by the texture analysis and the drug release followed Super case II transport. It is noteworthy that we described the preparation of a new cellulosic polymers based microsponge system for delivery of lornoxicam to provide quick as well as lasting (sustained) anti-inflammatory effects in rats using carrageenan induced rat paw edema model. We were able to demonstrate a 72% reduction in inflammation within 4 h using the optimize transdermal gel formulation utilizing Transcutol P as permeation enhancer and with the aid of skin micro-piercing by microneedles, hence, demonstrating the potential of this microsponge gel formulation in arthritis management.

Original languageEnglish
Pages (from-to)994-1003
Number of pages10
JournalSaudi Pharmaceutical Journal
Volume28
Issue number8
Early online date3 Jul 2020
DOIs
Publication statusPublished - 1 Aug 2020

Fingerprint Dive into the research topics of 'Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis'. Together they form a unique fingerprint.

Cite this