From frog integument to human skin

Dermatological perspectives from frog skin biology

Iain S. Haslam, Eric W. Roubos, Maria Luisa Mangoni, Katsutoshi Yoshizato, Hubert Vaudry, Jennifer E. Kloepper, David M. Pattwell, Paul F A Maderson, Ralf Paus

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

For over a century, frogs have been studied across various scientific fields, including physiology, embryology, neuroscience, (neuro)endocrinology, ecology, genetics, behavioural science, evolution, drug development, and conservation biology. In some cases, frog skin has proven very successful as a research model, for example aiding in the study of ion transport through tight epithelia, where it has served as a model for the vertebrate distal renal tubule and mammalian epithelia. However, it has rarely been considered in comparative studies involving human skin. Yet, despite certain notable adaptations that have enabled frogs to survive in both aquatic and terrestrial environments, frog skin has many features in common with human skin. Here we present a comprehensive overview of frog (and toad) skin ontogeny, anatomy, cytology, neuroendocrinology and immunology, with special attention to its unique adaptations as well as to its similarities with the mammalian integument, including human skin. We hope to provide a valuable reference point and a source of inspiration for both amphibian investigators and mammalian researchers studying the structural and functional properties of the largest organ of the vertebrate body.

Original languageEnglish
Pages (from-to)618-655
Number of pages38
JournalBiological Reviews
Volume89
Issue number3
Early online date3 Dec 2013
DOIs
Publication statusPublished - Aug 2014
Externally publishedYes

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integument
skin (animal)
Anura
frogs
Skin
Biological Sciences
Vertebrates
Endocrinology
epithelium
Epithelium
Distal Kidney Tubule
vertebrates
Research Personnel
Neuroendocrinology
Cytology
Immunology
Behavioral Sciences
renal tubules
endocrinology
neurophysiology

Cite this

Haslam, I. S., Roubos, E. W., Mangoni, M. L., Yoshizato, K., Vaudry, H., Kloepper, J. E., ... Paus, R. (2014). From frog integument to human skin: Dermatological perspectives from frog skin biology. Biological Reviews, 89(3), 618-655. https://doi.org/10.1111/brv.12072
Haslam, Iain S. ; Roubos, Eric W. ; Mangoni, Maria Luisa ; Yoshizato, Katsutoshi ; Vaudry, Hubert ; Kloepper, Jennifer E. ; Pattwell, David M. ; Maderson, Paul F A ; Paus, Ralf. / From frog integument to human skin : Dermatological perspectives from frog skin biology. In: Biological Reviews. 2014 ; Vol. 89, No. 3. pp. 618-655.
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Haslam, IS, Roubos, EW, Mangoni, ML, Yoshizato, K, Vaudry, H, Kloepper, JE, Pattwell, DM, Maderson, PFA & Paus, R 2014, 'From frog integument to human skin: Dermatological perspectives from frog skin biology', Biological Reviews, vol. 89, no. 3, pp. 618-655. https://doi.org/10.1111/brv.12072

From frog integument to human skin : Dermatological perspectives from frog skin biology. / Haslam, Iain S.; Roubos, Eric W.; Mangoni, Maria Luisa; Yoshizato, Katsutoshi; Vaudry, Hubert; Kloepper, Jennifer E.; Pattwell, David M.; Maderson, Paul F A; Paus, Ralf.

In: Biological Reviews, Vol. 89, No. 3, 08.2014, p. 618-655.

Research output: Contribution to journalArticle

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