G-Quadruplex Binding of a NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies

Kateřina Peterková, Mark Stitch, Rayhaan Boota, Paul Scattergood, Paul Elliott, Michael Towrie, Peter Podbevšek, Janez Plavec, Susan Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

G-quadruplexes are emerging targets in cancer research and understanding how diagnostic probes bind to DNA G-quadruplexes in solution is critical to the development of new molecular tools. In this study the binding of an enantiopure NIR emitting [Os(TAP)2(dppz)]2+complex to different G-quadruplex structures formed by human telomer (hTel) and cMYC sequences in solution is reported. The combination of NMR and time-resolved infrared spectroscopic techniques reveals the sensitivity of the emission response to subtle changes in the binding environment of the complex. 
Original languageEnglish
JournalChemistry - A European Journal
DOIs
Publication statusAccepted/In press - 17 Nov 2022

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