G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies

Kateřina Peterková, Mark Stitch, Rayhaan Boota, Paul Scattergood, Paul Elliott, Michael Towrie, Peter Podbevšek, Janez Plavec, Susan Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

G-quadruplexes are emerging targets in cancer research and understanding how diagnostic probes bind to DNA G-quadruplexes in solution is critical to the development of new molecular tools. In this study the binding of an enantiopure NIR emitting [Os(TAP) 2(dppz)] 2+ complex to different G-quadruplex structures formed by human telomer (hTel) and cMYC sequences in solution is reported. The combination of NMR and time-resolved infrared spectroscopic techniques reveals the sensitivity of the emission response to subtle changes in the binding environment of the complex. Similar behaviour is also observed for the related complex [Os(TAP) 2(dppp2)] 2+ upon quadruplex binding.

Original languageEnglish
Article numbere202203250
Number of pages7
JournalChemistry - A European Journal
Early online date12 Jan 2023
DOIs
Publication statusE-pub ahead of print - 12 Jan 2023

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