Activities per year
Abstract
G-quadruplexes are emerging targets in cancer research and understanding how diagnostic probes bind to DNA G-quadruplexes in solution is critical to the development of new molecular tools. In this study the binding of an enantiopure NIR emitting [Os(TAP) 2(dppz)] 2+ complex to different G-quadruplex structures formed by human telomer (hTel) and cMYC sequences in solution is reported. The combination of NMR and time-resolved infrared spectroscopic techniques reveals the sensitivity of the emission response to subtle changes in the binding environment of the complex. Similar behaviour is also observed for the related complex [Os(TAP) 2(dppp2)] 2+ upon quadruplex binding.
Original language | English |
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Article number | e202203250 |
Number of pages | 7 |
Journal | Chemistry - A European Journal |
Volume | 29 |
Issue number | 11 |
Early online date | 12 Jan 2023 |
DOIs | |
Publication status | Published - 21 Feb 2023 |
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Dive into the research topics of 'G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies'. Together they form a unique fingerprint.Activities
- 1 Visiting an external academic institution
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University College Dublin
Paul Scattergood (Visiting Research Fellow)
19 Jun 2023 → 23 Jun 2023Activity: External Appointments and Visits › Visiting an external academic institution
Datasets
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NMR titration experiments that study binding of a NIR emitting osmium polypyridyl probe to cMYC and hTel G-quadruplex DNA
Peterková, K. (Creator), Plavec, J. (Contributor), Quinn, S. J. (Contributor), Podbevšek, P. (Contributor), Stitch, M. (Contributor), Boota, R. (Contributor), Scattergood, P. A. (Contributor) & Elliott, P. (Contributor), Zenodo, 14 Oct 2022
Dataset