GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit

A Biophysical Model

Junxiu Liu, Liam McDaid, Alfonso Araque, John Wade, Jim Harkin, Shvan Karim, David Henshall , Niamh Connolly, Anju Johnson, Andy Tyrrell, Jon Timmis, Alan Millard, James Hilder, David Halliday

Research output: Contribution to journalArticle

Abstract

It is now widely accepted that glia cells and gamma-aminobutyric acidergic (GABA) interneurons dynamically regulate synaptic transmission and neuronal activity in time and space. This paper presents a biophysical model that captures the interaction between an astrocyte cell, a GABA interneuron and pre/postsynaptic neurons. Specifically, GABA released from a GABA interneuron triggers in astrocytes the release of calcium (Ca 2+) from the endoplasmic reticulum via the inositol 1, 4, 5-trisphosphate (IP 3) pathway. This results in gliotransmission which elevates the presynaptic transmission probability rate (PR) causing weight potentiation and a gradual increase in postsynaptic neuronal firing, that eventually stabilizes. However, by capturing the complex interactions between IP 3, generated from both GABA and the 2-arachidonyl glycerol (2-AG) pathway, and PR, this paper shows that this interaction not only gives rise to an initial weight potentiation phase but also this phase is followed by postsynaptic bursting behavior. Moreover, the model will show that there is a presynaptic frequency range over which burst firing can occur. The proposed model offers a novel cellular level mechanism that may underpin both seizure-like activity and neuronal synchrony across different brain regions.

Original languageEnglish
Article number335
Pages (from-to)1-14
Number of pages14
JournalFrontiers in Cellular Neuroscience
Volume13
Early online date23 Jul 2019
DOIs
Publication statusPublished - 23 Jul 2019
Externally publishedYes

Fingerprint

Interneurons
Astrocytes
Weights and Measures
Inositol 1,4,5-Trisphosphate
Synaptic Transmission
Neuroglia
Endoplasmic Reticulum
Seizures
Calcium
Neurons
Brain

Cite this

Liu, J., McDaid, L., Araque, A., Wade, J., Harkin, J., Karim, S., ... Halliday, D. (2019). GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model. Frontiers in Cellular Neuroscience, 13, 1-14. [335]. https://doi.org/10.3389/fncel.2019.00335
Liu, Junxiu ; McDaid, Liam ; Araque, Alfonso ; Wade, John ; Harkin, Jim ; Karim, Shvan ; Henshall , David ; Connolly, Niamh ; Johnson, Anju ; Tyrrell, Andy ; Timmis, Jon ; Millard, Alan ; Hilder, James ; Halliday, David. / GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit : A Biophysical Model. In: Frontiers in Cellular Neuroscience. 2019 ; Vol. 13. pp. 1-14.
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Liu, J, McDaid, L, Araque, A, Wade, J, Harkin, J, Karim, S, Henshall , D, Connolly, N, Johnson, A, Tyrrell, A, Timmis, J, Millard, A, Hilder, J & Halliday, D 2019, 'GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model', Frontiers in Cellular Neuroscience, vol. 13, 335, pp. 1-14. https://doi.org/10.3389/fncel.2019.00335

GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit : A Biophysical Model. / Liu, Junxiu; McDaid, Liam; Araque, Alfonso ; Wade, John; Harkin, Jim; Karim, Shvan; Henshall , David ; Connolly, Niamh; Johnson, Anju; Tyrrell, Andy ; Timmis, Jon; Millard, Alan; Hilder, James; Halliday, David.

In: Frontiers in Cellular Neuroscience, Vol. 13, 335, 23.07.2019, p. 1-14.

Research output: Contribution to journalArticle

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T2 - A Biophysical Model

AU - Liu, Junxiu

AU - McDaid, Liam

AU - Araque, Alfonso

AU - Wade, John

AU - Harkin, Jim

AU - Karim, Shvan

AU - Henshall , David

AU - Connolly, Niamh

AU - Johnson, Anju

AU - Tyrrell, Andy

AU - Timmis, Jon

AU - Millard, Alan

AU - Hilder, James

AU - Halliday, David

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KW - burst firing

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KW - calcium oscillation

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