Gastrointestinal tract effects of Securidaca longepedunculata root extract

Olumayokun A. Olajide, F. F. Ajayi, A. I. Ekhelar, S. O. Awe, J. M. Makinde, A. R.A. Alada

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Abstract

A methanol extract of the root of Securidaca longepedunculata has shown spasmodic actions on the gastrointestinal tract of laboratory animals. An increase in the propulsive movements of the intestinal contents, as well as a reduction in gastric emptying time, was produced by the extract. The number of wet faeces was increased in rats after oral administration. Preliminary studies on isolated guinea-pig ileum showed that the extract evoked contractions which were blocked by atropine. At a high dose, the extract produced ulcerations on gastric mucosa and small intestine.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
JournalPharmaceutical Biology
Volume37
Issue number2
DOIs
Publication statusPublished - 6 Nov 1999
Externally publishedYes

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Olajide, O. A., Ajayi, F. F., Ekhelar, A. I., Awe, S. O., Makinde, J. M., & Alada, A. R. A. (1999). Gastrointestinal tract effects of Securidaca longepedunculata root extract. Pharmaceutical Biology, 37(2), 134-137. https://doi.org/10.1076/phbi.37.2.134.6078