GEN-RWD Sandbox ecosystem for privacy-preserving data sharing in healthcare research: the Processor module

Benedetta Gottardelli, Roberto Gatta, Leonardo Nucciarelli, Mariachiara Savino, Andrada Mihaela Tudor, Mauro Vallati, Andrea Damiani

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Recent innovations in computer science and informatics are driving the integration of AI into modern healthcare, extending its applications to medical sectors previously reliant on human expertise. Creating robust and clinically relevant AI models requires extensive data, which can be challenging to gather, particularly when dealing with rare diseases. Data sharing among healthcare entities can address this issue, but legal, privacy, and data ownership concerns hinder such approach. To foster data sharing, in this paper we propose the GEmelli GeNerator – Real World Data (GEN-RWD) Sandbox, that provides a secure environment for data analysis without compromising sensitive medical data. This modular architecture serves as a research platform for various stakeholders, including clinical researchers, policymakers, and pharmaceutical companies. Authorized users submit research requests through the GUI, which are processed within the hospital, and the results can be accessed without revealing the original clinical data source. In the context of this paper we present GEN-RWD Sandbox’s architecture module in charge of executing the analysis requests, the Processor. Processor’s code is openly shared as the GSProcessor R package available at
Original languageEnglish
Title of host publicationProceedings of the 12th IEEE International Conference on Healthcare Informatics
Number of pages6
Publication statusAccepted/In press - 14 Mar 2024
Event12th IEEE International Conference on Healthcare Informatics - Orlando, United States
Duration: 3 Jun 20246 Jun 2024
Conference number: 12


Conference12th IEEE International Conference on Healthcare Informatics
Abbreviated titleIEEE ICHI 2024
Country/TerritoryUnited States
Internet address

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