General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

Nicholas J. Baxter; Andrew P. Laws; Laurent J.H. Rigoreau; Michael I. Page

doi:10.1039/a907501a

General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

Nicholas J. Baxter, Andrew P. Laws, Laurent J.H. Rigoreau, Michael I. Page

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The hydrolysis of the four-membered ring sulfonamide N-benzyl β-sultam is catalysed by carboxylic acids, which is attributed to specific acid- nucleophilic catalysis with the intermediate formation of a mixed anhydride which can be trapped with aniline.

Original language	English
Pages (from-to)	2401-2402
Number of pages	2
Journal	Chemical Communications
Issue number	23
DOIs	https://doi.org/10.1039/a907501a
Publication status	Published - 7 Dec 1999

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@article{32e495e3a8c949a7a11e7d1f9cbde9ec,

title = "General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis",

abstract = "The hydrolysis of the four-membered ring sulfonamide N-benzyl β-sultam is catalysed by carboxylic acids, which is attributed to specific acid- nucleophilic catalysis with the intermediate formation of a mixed anhydride which can be trapped with aniline.",

author = "Baxter, {Nicholas J.} and Laws, {Andrew P.} and Rigoreau, {Laurent J.H.} and Page, {Michael I.}",

year = "1999",

month = dec,

day = "7",

doi = "10.1039/a907501a",

language = "English",

pages = "2401--2402",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "23",

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T1 - General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

AU - Baxter, Nicholas J.

AU - Laws, Andrew P.

AU - Rigoreau, Laurent J.H.

AU - Page, Michael I.

PY - 1999/12/7

Y1 - 1999/12/7

N2 - The hydrolysis of the four-membered ring sulfonamide N-benzyl β-sultam is catalysed by carboxylic acids, which is attributed to specific acid- nucleophilic catalysis with the intermediate formation of a mixed anhydride which can be trapped with aniline.

AB - The hydrolysis of the four-membered ring sulfonamide N-benzyl β-sultam is catalysed by carboxylic acids, which is attributed to specific acid- nucleophilic catalysis with the intermediate formation of a mixed anhydride which can be trapped with aniline.

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U2 - 10.1039/a907501a

DO - 10.1039/a907501a

M3 - Article

AN - SCOPUS:0033534125

SN - 1359-7345

SP - 2401

EP - 2402

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

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