Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

Axel M Hillmer, Antonia Flaquer, Sandra Hanneken, Sibylle Eigelshoven, Anne-Katrin Kortüm, Felix F Brockschmidt, Astrid Golla, Christine Metzen, Holger Thiele, Susanne Kolberg, Roman Reinartz, Regina C Betz, Thomas Ruzicka, Hans Christian Hennies, Roland Kruse, Markus M Nöthen

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Abstract

Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalAmerican Journal of Human Genetics
Volume82
Issue number3
Early online date21 Feb 2008
DOIs
Publication statusPublished - 3 Mar 2008
Externally publishedYes

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Hillmer, A. M., Flaquer, A., Hanneken, S., Eigelshoven, S., Kortüm, A-K., Brockschmidt, F. F., ... Nöthen, M. M. (2008). Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26. American Journal of Human Genetics, 82(3), 737-743. https://doi.org/10.1016/j.ajhg.2007.11.014