Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

Axel M Hillmer; Antonia Flaquer; Sandra Hanneken; Sibylle Eigelshoven; Anne-Katrin Kortüm; Felix F Brockschmidt; Astrid Golla; Christine Metzen; Holger Thiele; Susanne Kolberg; Roman Reinartz; Regina C Betz; Thomas Ruzicka; Hans Christian Hennies; Roland Kruse; Markus M Nöthen

doi:10.1016/j.ajhg.2007.11.014

Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

Axel M Hillmer, Antonia Flaquer, Sandra Hanneken, Sibylle Eigelshoven, Anne-Katrin Kortüm, Felix F Brockschmidt, Astrid Golla, Christine Metzen, Holger Thiele, Susanne Kolberg, Roman Reinartz, Regina C Betz, Thomas Ruzicka, Hans Christian Hennies, Roland Kruse, Markus M Nöthen

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Abstract

Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

Original language	English
Pages (from-to)	737-743
Number of pages	7
Journal	American Journal of Human Genetics
Volume	82
Issue number	3
Early online date	21 Feb 2008
DOIs	https://doi.org/10.1016/j.ajhg.2007.11.014
Publication status	Published - 3 Mar 2008
Externally published	Yes

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Hillmer, A. M., Flaquer, A., Hanneken, S., Eigelshoven, S., Kortüm, A-K., Brockschmidt, F. F., Golla, A., Metzen, C., Thiele, H., Kolberg, S., Reinartz, R., Betz, R. C., Ruzicka, T., Hennies, H. C., Kruse, R., & Nöthen, M. M. (2008). Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26. American Journal of Human Genetics, 82(3), 737-743. https://doi.org/10.1016/j.ajhg.2007.11.014

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title = "Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26",

abstract = "Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.",

keywords = "Adult, Age of Onset, Alopecia, Chromosome Mapping, Chromosomes, Human, Pair 3, Family, Genetic Linkage, Genetic Predisposition to Disease, Genetic Testing, Genome, Human, Humans, Male, Journal Article, Research Support, Non-U.S. Gov't",

author = "Hillmer, {Axel M} and Antonia Flaquer and Sandra Hanneken and Sibylle Eigelshoven and Anne-Katrin Kort{\"u}m and Brockschmidt, {Felix F} and Astrid Golla and Christine Metzen and Holger Thiele and Susanne Kolberg and Roman Reinartz and Betz, {Regina C} and Thomas Ruzicka and Hennies, {Hans Christian} and Roland Kruse and N{\"o}then, {Markus M}",

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doi = "10.1016/j.ajhg.2007.11.014",

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Hillmer, AM, Flaquer, A, Hanneken, S, Eigelshoven, S, Kortüm, A-K, Brockschmidt, FF, Golla, A, Metzen, C, Thiele, H, Kolberg, S, Reinartz, R, Betz, RC, Ruzicka, T, Hennies, HC, Kruse, R & Nöthen, MM 2008, 'Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26', American Journal of Human Genetics, vol. 82, no. 3, pp. 737-743. https://doi.org/10.1016/j.ajhg.2007.11.014

TY - JOUR

T1 - Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

AU - Hillmer, Axel M

AU - Flaquer, Antonia

AU - Hanneken, Sandra

AU - Eigelshoven, Sibylle

AU - Kortüm, Anne-Katrin

AU - Brockschmidt, Felix F

AU - Golla, Astrid

AU - Metzen, Christine

AU - Thiele, Holger

AU - Kolberg, Susanne

AU - Reinartz, Roman

AU - Betz, Regina C

AU - Ruzicka, Thomas

AU - Hennies, Hans Christian

AU - Kruse, Roland

AU - Nöthen, Markus M

PY - 2008/3/3

Y1 - 2008/3/3

N2 - Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

AB - Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

KW - Adult

KW - Age of Onset

KW - Alopecia

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 3

KW - Family

KW - Genetic Linkage

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genome, Human

KW - Humans

KW - Male

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - http://www.cell.com/ajhg/home

U2 - 10.1016/j.ajhg.2007.11.014

DO - 10.1016/j.ajhg.2007.11.014

M3 - Article

C2 - 18304493

VL - 82

SP - 737

EP - 743

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 3

ER -

Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

Abstract

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