Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion

Nazli Khatib, Shilpa Gaidhane, Abhay M. Gaidhane, Mahanaaz Khatib, Padama Simkhada, Dilip Gode, Quazi Syed Zahiruddin

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of growth hormone (GH). It is a first hormone linking gastrointestinal-pituitary axis. Objective: This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends to explore the possible physiological role of the ghrelin-pituitary-GH axis linkage system. Observation: Ghrelin is highly conserved among species and is classified into octanoylated (C8:0), decanoylated (C10:0), decenoylated (C10:1) and nonacylated,ghrelin. Acylated ghrelin is the major active form of human ghrelin. The primary production site of ghrelin is the stomach, and it interacts with stomach ghrelin as well as hypothalamic GHRH and somatostatin in the regulation of pituitary GH secretion. Ghrelin stimulate GH release through the GHS receptor to increase intracellular Ca2+ ([Ca2+] levels via IP3 signal transduction pathway. Ghrelin is a specific endogenous ligand for the GHS receptor and provides a definitive proof of the occurance of a GHS-GHS receptor signalling system in the regulation of GH secretion. Conclusion: Studies suggests that ghrelin is a powerful pharmacological agent that exerts a potent, time-dependent stimulation of pulsatile secretion of GH.

Original languageEnglish
Pages (from-to)MC13 - MC17
Number of pages5
JournalJournal of Clinical and Diagnostic Research
Volume8
Issue number8
DOIs
Publication statusPublished - 20 Aug 2014
Externally publishedYes

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    Khatib, N., Gaidhane, S., Gaidhane, A. M., Khatib, M., Simkhada, P., Gode, D., & Zahiruddin, Q. S. (2014). Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion. Journal of Clinical and Diagnostic Research, 8(8), MC13 - MC17. https://doi.org/10.7860/JCDR/2014/9863.4767