Glucose-derived palladium(0) nanoparticles as in situ-formed catalysts for suzuki-miyaura cross-coupling reactions in isopropanol

Jason E. Camp, Jay J. Dunsford, Edward P. Cannons, William J. Restorick, Anastasia Gadzhieva, Michael W. Fay, Robert J. Smith

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Effective and convenient protocols using renewable sugar-derived palladium(0) nanoparticles (PdNPs) as in situ-formed catalysts for Suzuki-Miyaura cross-coupling reactions in isopropanol under thermal and microwave heating conditions have been developed. The addition of a small amount of glucose (5 mol %) to the reaction mixture lead to an increase in yield of the cross-coupled products compared to control experiments that omitted glucose. The size and morphology of the in situ-formed PdNPs were determined by TEM, and further EF-TEM analysis showed a hydrophilic hydroxylated shell around the individual palladium particles. The polar/hydrophilic nature of the nanoparticles allowed for their facile removal from the cross-coupled product, and a significant decrease in the amount of palladium incorporated into the final product was observed, as measured by ICP-MS analysis.

Original languageEnglish
Pages (from-to)500-505
Number of pages6
JournalACS Sustainable Chemistry and Engineering
Issue number3
Early online date18 Nov 2013
Publication statusPublished - 3 Mar 2014
Externally publishedYes


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