Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

J. Bentley, I. Walker, E. McIntosh, A. D. Whetton, P. J. Owen-Lynch, S. A. Baldwin

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr-Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upregulation of glucose transport was mediated by phosphatidylinositol-3kinase. The observation that Bcr-Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.

Original languageEnglish
Pages (from-to)212-215
Number of pages4
JournalBritish Journal of Haematology
Volume112
Issue number1
DOIs
Publication statusPublished - 1 Jan 2001
Externally publishedYes

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Chronic Phase
Glucose
bcr-abl Fusion Proteins
Myeloid Cells
Phosphatidylinositols
Oncogenes
Protein-Tyrosine Kinases
Cell Survival
Up-Regulation
Stem Cells
Cytokines
Cell Line
Food

Cite this

Bentley, J. ; Walker, I. ; McIntosh, E. ; Whetton, A. D. ; Owen-Lynch, P. J. ; Baldwin, S. A. / Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. In: British Journal of Haematology. 2001 ; Vol. 112, No. 1. pp. 212-215.
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Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. / Bentley, J.; Walker, I.; McIntosh, E.; Whetton, A. D.; Owen-Lynch, P. J.; Baldwin, S. A.

In: British Journal of Haematology, Vol. 112, No. 1, 01.01.2001, p. 212-215.

Research output: Contribution to journalArticle

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