Abstract
The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr-Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upregulation of glucose transport was mediated by phosphatidylinositol-3kinase. The observation that Bcr-Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.
Original language | English |
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Pages (from-to) | 212-215 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 112 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2001 |
Externally published | Yes |