Grewia polysaccharide as a pharmaceutical excipient in matrix tablets

Elijah I. Nep, Barbara R. Conway

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and kinetics of drug release were also investigated. In vitro drug release studies, in phosphate buffer (pH 7.2) using USP type II apparatus, revealed that grewia gum at concentrations of 16%, 32% and 48% can sustain the release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and ibuprofen release was by anomalous diffusion in accordance with the Korsmeyer-Peppas model. There was evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from tablets when used in the ratio 2:1. Grewia gum may therefore prove a useful excipient, when used on its own, or in combination with other polymers, to modify drug release.

LanguageEnglish
Pages3-15
Number of pages13
JournalJournal of Excipients and Food Chemicals
Volume2
Issue number1
Publication statusPublished - 2011

Fingerprint

Grewia
Excipients
ibuprofen
Tablets
Polysaccharides
guar gum
polysaccharides
Ibuprofen
drugs
Pharmaceutical Preparations
polymers
cellulose
Polymers
synergism
pharmacokinetics
buffers
phosphates
Buffers
Phosphates

Cite this

@article{6037ab9cd4234ff085ff7023f30a5d8a,
title = "Grewia polysaccharide as a pharmaceutical excipient in matrix tablets",
abstract = "Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and kinetics of drug release were also investigated. In vitro drug release studies, in phosphate buffer (pH 7.2) using USP type II apparatus, revealed that grewia gum at concentrations of 16{\%}, 32{\%} and 48{\%} can sustain the release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and ibuprofen release was by anomalous diffusion in accordance with the Korsmeyer-Peppas model. There was evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from tablets when used in the ratio 2:1. Grewia gum may therefore prove a useful excipient, when used on its own, or in combination with other polymers, to modify drug release.",
keywords = "Controlled delivery, Drug release, Erosion, Ibuprofen, Release profile, Swelling",
author = "Nep, {Elijah I.} and Conway, {Barbara R.}",
year = "2011",
language = "English",
volume = "2",
pages = "3--15",
journal = "Journal of Excipients and Food Chemicals",
issn = "2150-2668",
publisher = "IPEC-Americas",
number = "1",

}

Grewia polysaccharide as a pharmaceutical excipient in matrix tablets. / Nep, Elijah I.; Conway, Barbara R.

In: Journal of Excipients and Food Chemicals, Vol. 2, No. 1, 2011, p. 3-15.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Grewia polysaccharide as a pharmaceutical excipient in matrix tablets

AU - Nep, Elijah I.

AU - Conway, Barbara R.

PY - 2011

Y1 - 2011

N2 - Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and kinetics of drug release were also investigated. In vitro drug release studies, in phosphate buffer (pH 7.2) using USP type II apparatus, revealed that grewia gum at concentrations of 16%, 32% and 48% can sustain the release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and ibuprofen release was by anomalous diffusion in accordance with the Korsmeyer-Peppas model. There was evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from tablets when used in the ratio 2:1. Grewia gum may therefore prove a useful excipient, when used on its own, or in combination with other polymers, to modify drug release.

AB - Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and kinetics of drug release were also investigated. In vitro drug release studies, in phosphate buffer (pH 7.2) using USP type II apparatus, revealed that grewia gum at concentrations of 16%, 32% and 48% can sustain the release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and ibuprofen release was by anomalous diffusion in accordance with the Korsmeyer-Peppas model. There was evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from tablets when used in the ratio 2:1. Grewia gum may therefore prove a useful excipient, when used on its own, or in combination with other polymers, to modify drug release.

KW - Controlled delivery

KW - Drug release

KW - Erosion

KW - Ibuprofen

KW - Release profile

KW - Swelling

UR - http://www.scopus.com/inward/record.url?scp=79953281993&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 3

EP - 15

JO - Journal of Excipients and Food Chemicals

T2 - Journal of Excipients and Food Chemicals

JF - Journal of Excipients and Food Chemicals

SN - 2150-2668

IS - 1

ER -