High-modulus, melt spun polycaprolactone fibres for biomedical grafts

Tom O'Haire, Stephen J. Russell, Parikshit Goswami

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanical requirements for a graft or regenerative tissue scaffold can vary depending on the expected load and healing time for such a device. For synthetic tendon repair the graft should have mechanical properties that facilitate its surgical introduction and fixation and be capable of withstanding high tensile loading with limited extension during the recovery phase. Tendons have a tensile strength of 50 to 150 MPa and an elastic modulus of 550 MPa and upwards [1-3]. Finding a suitable synthetic material is often a compromise between mechanical performance and biocompatibility. Polycaprolactone (PCL) is known to have excellent properties as a biomaterial due to the favorable cytotoxic and cell growth response observed in vitro and in vivo. In addition, the biological breakdown time for PCL is acceptable for applications where the graft is expected to bear load for an extended period of healing [3]. However, the measured tensile properties of as-spun PCL is insufficient for high tenacity and high modulus applications [4, 5]. The post-spinning drawing of polycaprolactone is one option for increasing the mechanical properties of PCL.
LanguageEnglish
Title of host publicationFiber Society 2016 Spring Conference
Subtitle of host publicationTextile Innovations - Opportunities and Challenges
PublisherKOREAN FIBER SOCIETY
ISBN (Electronic)9782955656006
Publication statusPublished - 2016
Externally publishedYes
EventFiber Society Spring Meeting and Technical Conference 2016: Textile Innovations - Opportunities and Challenges - Mulhouse, France
Duration: 25 May 201627 May 2016
http://toc.proceedings.com/32359webtoc.pdf (Link to Conference Proceedings)

Conference

ConferenceFiber Society Spring Meeting and Technical Conference 2016
CountryFrance
CityMulhouse
Period25/05/1627/05/16
Internet address

Fingerprint

Polycaprolactone
Grafts
Fibers
Tendons
Tissue Scaffolds
Mechanical properties
Tenacity
Cell growth
Biocompatible Materials
Biocompatibility
Tensile properties
Biomaterials
Repair
Tensile strength
Elastic moduli
polycaprolactone
Recovery

Cite this

O'Haire, T., Russell, S. J., & Goswami, P. (2016). High-modulus, melt spun polycaprolactone fibres for biomedical grafts. In Fiber Society 2016 Spring Conference: Textile Innovations - Opportunities and Challenges KOREAN FIBER SOCIETY.
O'Haire, Tom ; Russell, Stephen J. ; Goswami, Parikshit. / High-modulus, melt spun polycaprolactone fibres for biomedical grafts. Fiber Society 2016 Spring Conference: Textile Innovations - Opportunities and Challenges. KOREAN FIBER SOCIETY, 2016.
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O'Haire, T, Russell, SJ & Goswami, P 2016, High-modulus, melt spun polycaprolactone fibres for biomedical grafts. in Fiber Society 2016 Spring Conference: Textile Innovations - Opportunities and Challenges. KOREAN FIBER SOCIETY, Fiber Society Spring Meeting and Technical Conference 2016, Mulhouse, France, 25/05/16.

High-modulus, melt spun polycaprolactone fibres for biomedical grafts. / O'Haire, Tom; Russell, Stephen J.; Goswami, Parikshit.

Fiber Society 2016 Spring Conference: Textile Innovations - Opportunities and Challenges. KOREAN FIBER SOCIETY, 2016.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - The mechanical requirements for a graft or regenerative tissue scaffold can vary depending on the expected load and healing time for such a device. For synthetic tendon repair the graft should have mechanical properties that facilitate its surgical introduction and fixation and be capable of withstanding high tensile loading with limited extension during the recovery phase. Tendons have a tensile strength of 50 to 150 MPa and an elastic modulus of 550 MPa and upwards [1-3]. Finding a suitable synthetic material is often a compromise between mechanical performance and biocompatibility. Polycaprolactone (PCL) is known to have excellent properties as a biomaterial due to the favorable cytotoxic and cell growth response observed in vitro and in vivo. In addition, the biological breakdown time for PCL is acceptable for applications where the graft is expected to bear load for an extended period of healing [3]. However, the measured tensile properties of as-spun PCL is insufficient for high tenacity and high modulus applications [4, 5]. The post-spinning drawing of polycaprolactone is one option for increasing the mechanical properties of PCL.

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O'Haire T, Russell SJ, Goswami P. High-modulus, melt spun polycaprolactone fibres for biomedical grafts. In Fiber Society 2016 Spring Conference: Textile Innovations - Opportunities and Challenges. KOREAN FIBER SOCIETY. 2016