TY - JOUR
T1 - High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix
AU - Gramaglia, Daniela
AU - Conway, Barbara R.
AU - Kett, Vicky L.
AU - Malcolm, R. Karl
AU - Batchelor, Hannah K.
PY - 2005/9/14
Y1 - 2005/9/14
N2 - Conventional differential scanning calorimetry (DSC) techniques are commonly used to quantify the solubility of drugs within polymeric-controlled delivery systems. However, the nature of the DSC experiment, and in particular the relatively slow heating rates employed, limit its use to the measurement of drug solubility at the drug's melting temperature. Here, we describe the application of hyper-DSC (HDSC), a variant of DSC involving extremely rapid heating rates, to the calculation of the solubility of a model drug, metronidazole, in silicone elastomer, and demonstrate that the faster heating rates permit the solubility to be calculated under non-equilibrium conditions such that the solubility better approximates that at the temperature of use. At a heating rate of 400°C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20°C/min.
AB - Conventional differential scanning calorimetry (DSC) techniques are commonly used to quantify the solubility of drugs within polymeric-controlled delivery systems. However, the nature of the DSC experiment, and in particular the relatively slow heating rates employed, limit its use to the measurement of drug solubility at the drug's melting temperature. Here, we describe the application of hyper-DSC (HDSC), a variant of DSC involving extremely rapid heating rates, to the calculation of the solubility of a model drug, metronidazole, in silicone elastomer, and demonstrate that the faster heating rates permit the solubility to be calculated under non-equilibrium conditions such that the solubility better approximates that at the temperature of use. At a heating rate of 400°C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20°C/min.
KW - High-speed DSC
KW - Metronidazole
KW - Silicone
KW - Solubility
UR - http://www.scopus.com/inward/record.url?scp=23944515791&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2005.04.038
DO - 10.1016/j.ijpharm.2005.04.038
M3 - Article
C2 - 16061335
AN - SCOPUS:23944515791
VL - 301
SP - 1
EP - 5
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -