Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
Shepherd, J., Swift, T., Chang, C-Y., Boyne, J., Rimmer, S., & Martin, W. (2019). Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. Chemical Communications, 55(66), 9765-9768. https://doi.org/10.1039/c9cc02524c