Abstract
Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
Original language | English |
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Pages (from-to) | 9765-9768 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 66 |
DOIs | |
Publication status | Published - 29 Jul 2019 |
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Profiles
-
James Boyne
- Department of Biological and Geographical Sciences - Reader
- School of Applied Sciences
- Centre for Biomarker Research - Member
- Cellular and Molecular Models of Disease Centre - Associate Member
Person: Academic