Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum

Joanna Shepherd; Thomas Swift; Chien-Yi Chang; James Boyne; Stephen Rimmer; William Martin

doi:10.1039/c9cc02524c

Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum

Joanna Shepherd, Thomas Swift, Chien-Yi Chang, James Boyne, Stephen Rimmer, William Martin

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

Original language	English
Pages (from-to)	9765-9768
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	66
DOIs	https://doi.org/10.1039/c9cc02524c
Publication status	Published - 29 Jul 2019

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10.1039/c9cc02524cLicence: CC BY

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James Boyne
- J.R.Boyne@hud.ac.uk
- Department of Biological and Geographical Sciences - Reader
- School of Applied Sciences
- Centre for Biomarker Research - Member
- Cellular and Molecular Models of Disease Centre - Associate Member
Person: Academic

Cite this

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title = "Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum",

abstract = "Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.",

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Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. / Shepherd, Joanna; Swift, Thomas; Chang, Chien-Yi; Boyne, James; Rimmer, Stephen; Martin, William.

In: Chemical Communications, Vol. 55, No. 66, 29.07.2019, p. 9765-9768.

Research output: Contribution to journal › Article › peer-review

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