Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum

Joanna Shepherd, Thomas Swift, Chien-Yi Chang, James Boyne, Stephen Rimmer, William Martin

Research output: Contribution to journal › Article

Abstract

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
LanguageEnglish
Pages9765-9768
Number of pages4
JournalChemical Communications
Volume55
Issue number66
Publication statusPublished - 29 Jul 2019

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Functional materials
Biofilms
Antibiotics
Assays
Polymers
Anti-Bacterial Agents
Molecules
poly-N-isopropylacrylamide
homoserine lactone

Cite this

Shepherd, Joanna ; Swift, Thomas ; Chang, Chien-Yi ; Boyne, James ; Rimmer, Stephen ; Martin, William. / Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. In: Chemical Communications. 2019 ; Vol. 55, No. 66. pp. 9765-9768.
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Shepherd, J, Swift, T, Chang, C-Y, Boyne, J, Rimmer, S & Martin, W 2019, 'Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum', Chemical Communications, vol. 55, no. 66, pp. 9765-9768.

Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. / Shepherd, Joanna; Swift, Thomas; Chang, Chien-Yi; Boyne, James; Rimmer, Stephen; Martin, William.

In: Chemical Communications, Vol. 55, No. 66, 29.07.2019, p. 9765-9768.

Research output: Contribution to journal › Article

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AU - Swift, Thomas

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AU - Boyne, James

AU - Rimmer, Stephen

AU - Martin, William

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AB - Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

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Shepherd J, Swift T, Chang C-Y, Boyne J, Rimmer S, Martin W. Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. Chemical Communications. 2019 Jul 29;55(66):9765-9768.