Abstract
Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
| Original language | English |
|---|---|
| Pages (from-to) | 9765-9768 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 66 |
| DOIs | |
| Publication status | Published - 29 Jul 2019 |
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Profiles
James Boyne
- Department of Biological and Geographical Sciences - Reader
- School of Applied Sciences
- Cellular and Molecular Models of Disease Centre - Associate Member
- Pharmacology and Therapeutics Centre - Member
Person: Academic
Cite this
Shepherd, J., Swift, T., Chang, C-Y., Boyne, J., Rimmer, S., & Martin, W. (2019). Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. Chemical Communications, 55(66), 9765-9768. https://doi.org/10.1039/c9cc02524c