Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 9765-9768 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 55 |
| Issue number | 66 |
| DOIs | |
| Publication status | Published - 29 Jul 2019 |
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Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum. / Shepherd, Joanna; Swift, Thomas; Chang, Chien-Yi; Boyne, James; Rimmer, Stephen; Martin, William.
In: Chemical Communications, Vol. 55, No. 66, 29.07.2019, p. 9765-9768.Research output: Contribution to journal › Article
TY - JOUR
T1 - Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum
AU - Shepherd, Joanna
AU - Swift, Thomas
AU - Chang, Chien-Yi
AU - Boyne, James
AU - Rimmer, Stephen
AU - Martin, William
PY - 2019/7/29
Y1 - 2019/7/29
N2 - Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
AB - Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
UR - http://www.scopus.com/inward/record.url?scp=85070633290&partnerID=8YFLogxK
U2 - 10.1039/c9cc02524c
DO - 10.1039/c9cc02524c
M3 - Article
VL - 55
SP - 9765
EP - 9768
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 66
ER -