Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum

Joanna Shepherd; Thomas Swift; Chien-Yi Chang; James Boyne; Stephen Rimmer; William Martin

doi:10.1039/c9cc02524c

Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum

Joanna Shepherd, Thomas Swift, Chien-Yi Chang, James Boyne, Stephen Rimmer, William Martin

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

Original language	English
Pages (from-to)	9765-9768
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	66
DOIs	https://doi.org/10.1039/c9cc02524c
Publication status	Published - 29 Jul 2019

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SDG 3 Good Health and Well-being

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10.1039/c9cc02524cLicence: CC BY

Chem Comm accepted manuscriptAccepted author manuscript, 880 KBLicence: Unspecified

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title = "Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum",

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AU - Shepherd, Joanna

AU - Swift, Thomas

AU - Chang, Chien-Yi

AU - Boyne, James

AU - Rimmer, Stephen

AU - Martin, William

PY - 2019/7/29

Y1 - 2019/7/29

N2 - Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

AB - Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

KW - Quorum sensing

KW - Acyl-Butyrolactones

KW - N-Octanoylhomoserine lactone

UR - https://www.scopus.com/pages/publications/85070633290

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JO - Chemical Communications

JF - Chemical Communications

IS - 66

ER -

Highly Branched Poly(N-isopropyl acrylamide) Functionalized with an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium violaceum

Abstract

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