Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones

Steven M. Allin, Darshan G. Vaidya, Michael I. Page, Alexandra M.Z. Slawin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalArkivoc
Volume2000
Issue number2 SPEC.ISS.
DOIs
Publication statusPublished - 3 May 2000

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