TY - JOUR
T1 - Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones
AU - Allin, Steven M.
AU - Vaidya, Darshan G.
AU - Page, Michael I.
AU - Slawin, Alexandra M.Z.
PY - 2000/5/3
Y1 - 2000/5/3
N2 - Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.
AB - Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.
KW - Thiazolo[2,3-a]isoindolin-5-ones
KW - diastereoselective synthesis
UR - http://www.scopus.com/inward/record.url?scp=0141938804&partnerID=8YFLogxK
U2 - 10.3998/ark.5550190.0001.209
DO - 10.3998/ark.5550190.0001.209
M3 - Article
AN - SCOPUS:0141938804
VL - 2000
SP - 151
EP - 157
JO - Arkivoc
JF - Arkivoc
SN - 1551-7004
IS - 2 SPEC.ISS.
ER -