Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions: The effect of wettability and dissolution

Maen Alshafiee, Mohammad K. Aljammal, Daniel Markl, Adam Ward, Karl Walton, Liam Blunt, Sachin Korde, Sudhir K. Pagire, Adrian L. Kelly, Anant Paradkar, Barbara R. Conway, Kofi Asare-Addo

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to evaluate the choice of polymer and polymer level on the performance of the microstructure and wettability of hot-melt extruded solid dispersion of Glyburide (Gly) as a model drug. The produced solid dispersion were characterised using scanning electron microscopy (SEM), image analysis using a focus variation instrument (FVI), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), X-ray microtomography (XµT), dynamic contact angle measurement and dissolution analysis using biorelevant dissolution media (FASSIF). SEM and focus variation analysis showed that the microstructure and surface morphology was significantly different between samples produced. This was confirmed by further analysis using XµT which showed that an increase in polymer content brought about a decrease in the porosity of the hot-melt extruded dispersions. DSC suggested complete amorphorisation of Gly whereas XRPD suggested incomplete amorphorisation. The static and dynamic contact angle measurement correlated with the dissolution studies using FASSIF media indicating that the initial liquid imbibition process as captured by the dynamic contact angle directly affects the dissolution performance.

LanguageEnglish
Pages245-254
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume559
Early online date27 Jan 2019
DOIs
Publication statusPublished - 25 Mar 2019

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Wettability
Glyburide
Powder Diffraction
Polymers
Differential Scanning Calorimetry
X-Ray Diffraction
Electron Scanning Microscopy
X-Ray Microtomography
Porosity
Pharmaceutical Preparations

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Alshafiee, Maen ; Aljammal, Mohammad K. ; Markl, Daniel ; Ward, Adam ; Walton, Karl ; Blunt, Liam ; Korde, Sachin ; Pagire, Sudhir K. ; Kelly, Adrian L. ; Paradkar, Anant ; Conway, Barbara R. ; Asare-Addo, Kofi. / Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions : The effect of wettability and dissolution. In: International Journal of Pharmaceutics. 2019 ; Vol. 559. pp. 245-254.
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abstract = "The aim of this study was to evaluate the choice of polymer and polymer level on the performance of the microstructure and wettability of hot-melt extruded solid dispersion of Glyburide (Gly) as a model drug. The produced solid dispersion were characterised using scanning electron microscopy (SEM), image analysis using a focus variation instrument (FVI), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), X-ray microtomography (XµT), dynamic contact angle measurement and dissolution analysis using biorelevant dissolution media (FASSIF). SEM and focus variation analysis showed that the microstructure and surface morphology was significantly different between samples produced. This was confirmed by further analysis using XµT which showed that an increase in polymer content brought about a decrease in the porosity of the hot-melt extruded dispersions. DSC suggested complete amorphorisation of Gly whereas XRPD suggested incomplete amorphorisation. The static and dynamic contact angle measurement correlated with the dissolution studies using FASSIF media indicating that the initial liquid imbibition process as captured by the dynamic contact angle directly affects the dissolution performance.",
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Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions : The effect of wettability and dissolution. / Alshafiee, Maen; Aljammal, Mohammad K.; Markl, Daniel; Ward, Adam; Walton, Karl; Blunt, Liam; Korde, Sachin; Pagire, Sudhir K.; Kelly, Adrian L.; Paradkar, Anant; Conway, Barbara R.; Asare-Addo, Kofi.

In: International Journal of Pharmaceutics, Vol. 559, 25.03.2019, p. 245-254.

Research output: Contribution to journalArticle

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AU - Walton, Karl

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AU - Pagire, Sudhir K.

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AU - Asare-Addo, Kofi

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