Hydro-Alcoholic Media Effects on Theophylline Release from Sesamum Polysaccharide Gum Matrices

Elijah I. Nep, Mohammed Mahdi, Adeola Adebisi, N. C. Ngwuluka, Barbara Conway, Alan Smith, Kofi Asare-Addo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Concomitant ingestion of alcohol and medications can greatly affect drug plasma concentrations as dose dumping or failure may occur as a result of the fact that formulation excipients may not always be resistant to alcohol. In this study, a natural polysaccharide (Sesamum radiatum gum) (SG) was extracted, characterized and used to formulate sustained release theophylline compacts to study the effect of varying alcohol concentrations (v/v) in dissolution media on drug release from these compacts. X-ray powder diffraction showed that the extracted gum was amorphous in nature with the powder having excellent compaction properties as observed with its compact being significantly harder than those prepared with pure hydroxypropyl methyl cellulose (HPMC) K4M. X-ray microtomography showed that the compacts produced were homogenous in nature, however, swelling studies showed failure of the compacts at the highest concentration of absolute ethanol used (40% v/v). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57–91) in simulated gastric (0.1 N HCl, pH 1.2) and intestinal fluids (phosphate buffer, pH 6.8) for the HPMC compacts whereas dissimilarity only occurred for the SG compacts at the highest alcohol concentration in both media (f2 = 35). The suitability of SG as a matrix former that can resist alcoholic effects therefore makes it suitable as an alternative polymer with wider applications for drug delivery.
Original languageEnglish
Pages (from-to)251-260
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume44
Issue number2
Early online date23 Oct 2017
DOIs
Publication statusPublished - 1 Feb 2018

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Sesamum
Gingiva
Theophylline
Polysaccharides
Alcohols
Dissolution
Powder Diffraction
X-Ray Microtomography
Excipients
Drug delivery
X-Ray Diffraction
Pharmaceutical Preparations
Powders
X ray powder diffraction
Swelling
Stomach
Buffers
Polymers
Compaction
Ethanol

Cite this

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abstract = "Concomitant ingestion of alcohol and medications can greatly affect drug plasma concentrations as dose dumping or failure may occur as a result of the fact that formulation excipients may not always be resistant to alcohol. In this study, a natural polysaccharide (Sesamum radiatum gum) (SG) was extracted, characterized and used to formulate sustained release theophylline compacts to study the effect of varying alcohol concentrations (v/v) in dissolution media on drug release from these compacts. X-ray powder diffraction showed that the extracted gum was amorphous in nature with the powder having excellent compaction properties as observed with its compact being significantly harder than those prepared with pure hydroxypropyl methyl cellulose (HPMC) K4M. X-ray microtomography showed that the compacts produced were homogenous in nature, however, swelling studies showed failure of the compacts at the highest concentration of absolute ethanol used (40{\%} v/v). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57–91) in simulated gastric (0.1 N HCl, pH 1.2) and intestinal fluids (phosphate buffer, pH 6.8) for the HPMC compacts whereas dissimilarity only occurred for the SG compacts at the highest alcohol concentration in both media (f2 = 35). The suitability of SG as a matrix former that can resist alcoholic effects therefore makes it suitable as an alternative polymer with wider applications for drug delivery.",
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Hydro-Alcoholic Media Effects on Theophylline Release from Sesamum Polysaccharide Gum Matrices. / Nep, Elijah I.; Mahdi, Mohammed; Adebisi, Adeola; Ngwuluka, N. C.; Conway, Barbara; Smith, Alan; Asare-Addo, Kofi.

In: Drug Development and Industrial Pharmacy, Vol. 44, No. 2, 01.02.2018, p. 251-260.

Research output: Contribution to journalArticle

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