Hydrocolloids and Medicinal Chemistry Applications

Liam M. Grover, Alan M. Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The techniques for delivering substances into the human body have been widely researched by humankind for literally thousands of years from both a medicinal and recreational perspective. This chapter focuses on biopolymers that are investigated to provide modified-release properties and the use of biopolymers in biopharmaceutical formulations. Biopolymers in particular are widely used within pharmaceutical products, traditionally as excipients such as binders, fillers, thickeners, and disintegrants. Apart from numerous applications in traditional dosage forms, biopolymers have recently been used for the controlled delivery of biological material such as proteins, peptides, and vaccines. Biopolymer-derived hydrogels are now used widely in the delivery of drugs and are finding increased use in the fabrication of tissue-engineered structures. Their biological compatibility in a range of applications and recent developments in microscale processing technologies means that one can exercise unprecedented control over their microstructures and regional variations in chemical and physical environments. As the requirement for tissue replacements increases and with the development of new biopharmaceutical products, their widespread application in regenerative medicine in the next decade is set to increase significantly.

Original languageEnglish
Title of host publicationModern Biopolymer Science
Subtitle of host publicationBridging the Divide between Fundamental Treatise and Industrial Application
EditorsStefan Kasapis, Ian Norton, Johan Ubbink
PublisherElsevier Inc.
Chapter18
Pages595-618
Number of pages24
Edition1
ISBN (Electronic)9780080921143
ISBN (Print)9780123741950
DOIs
Publication statusPublished - 31 Jul 2009

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