Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences

Some Caveats

Hans Jürgen Bandelt, C. Herrnstadt, Y. G. Yao, Q. P. Kong, T. Kivisild, C. Rengo, R. Scozzari, M. Richards, R. Villems, V. Macaulay, N. Howell, A. Torroni, Y. P. Zhang

Research output: Contribution to journalArticle

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Abstract

In this study, a detailed analysis of both previously published and new data was performed to determine whether complete, or almost complete, mtDNA sequences can resolve the long-debated issue of which Asian mtDNAs were founder sequences for the Native American mtDNA pool. Unfortunately, we now know that coding region data and their analysis are not without problems. To obtain and report reasonably correct sequences does not seem to be a trivial task, and to discriminate between Asian and Native American mtDNA ancestries may be more complex than previously believed. It is essential to take into account the effects of mutational hot spots in both the control and coding regions, so that the number of apparent Native American mtDNA founder sequences is not erroneously inflated. As we report here, a careful analysis of all available data indicates that there is very little evidence that more than five founder mtDNA sequences entered Beringia before the Last Glacial Maximum and left their traces in the current Native American mtDNA pool.

Original languageEnglish
Pages (from-to)512-524
Number of pages13
JournalAnnals of Human Genetics
Volume67
Issue number6
Early online date6 Oct 2003
DOIs
Publication statusPublished - Nov 2003

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North American Indians
Mitochondrial DNA
Asian Americans

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Bandelt, H. J., Herrnstadt, C., Yao, Y. G., Kong, Q. P., Kivisild, T., Rengo, C., ... Zhang, Y. P. (2003). Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences: Some Caveats. Annals of Human Genetics, 67(6), 512-524. https://doi.org/10.1046/j.1469-1809.2003.00049.x
Bandelt, Hans Jürgen ; Herrnstadt, C. ; Yao, Y. G. ; Kong, Q. P. ; Kivisild, T. ; Rengo, C. ; Scozzari, R. ; Richards, M. ; Villems, R. ; Macaulay, V. ; Howell, N. ; Torroni, A. ; Zhang, Y. P. / Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences : Some Caveats. In: Annals of Human Genetics. 2003 ; Vol. 67, No. 6. pp. 512-524.
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Bandelt, HJ, Herrnstadt, C, Yao, YG, Kong, QP, Kivisild, T, Rengo, C, Scozzari, R, Richards, M, Villems, R, Macaulay, V, Howell, N, Torroni, A & Zhang, YP 2003, 'Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences: Some Caveats', Annals of Human Genetics, vol. 67, no. 6, pp. 512-524. https://doi.org/10.1046/j.1469-1809.2003.00049.x

Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences : Some Caveats. / Bandelt, Hans Jürgen; Herrnstadt, C.; Yao, Y. G.; Kong, Q. P.; Kivisild, T.; Rengo, C.; Scozzari, R.; Richards, M.; Villems, R.; Macaulay, V.; Howell, N.; Torroni, A.; Zhang, Y. P.

In: Annals of Human Genetics, Vol. 67, No. 6, 11.2003, p. 512-524.

Research output: Contribution to journalArticle

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