Imide and isatin derivatives as γ-lactam mimics of β-lactamantibiotics

Peter S. Hadfield; Lorraine A. Casey; Ronald H.B. Galt; Bartholomew Vilanova; Michael I. Page

Imide and isatin derivatives as γ-lactam mimics of β-lactamantibiotics

Peter S. Hadfield, Lorraine A. Casey, Ronald H.B. Galt, Bartholomew Vilanova, Michael I. Page

Research output: Contribution to journal › Article › peer-review

Abstract

Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the β-lactam antibiotics and their chemical and biological reactivity determined.

Original language	English
Pages (from-to)	125-144
Number of pages	20
Journal	Arkivoc
Volume	2002
Issue number	6
Early online date	23 Aug 2002
Publication status	Published - Dec 2002

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title = "Imide and isatin derivatives as γ-lactam mimics of β-lactamantibiotics",

abstract = "Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the β-lactam antibiotics and their chemical and biological reactivity determined.",

keywords = "β-lactamase, γ-lactams, Antibacterials, Hydrolysis, Imides, Isatins",

author = "Hadfield, {Peter S.} and Casey, {Lorraine A.} and Galt, {Ronald H.B.} and Bartholomew Vilanova and Page, {Michael I.}",

year = "2002",

month = dec,

language = "English",

volume = "2002",

pages = "125--144",

journal = "Arkivoc",

issn = "1551-7004",

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TY - JOUR

T1 - Imide and isatin derivatives as γ-lactam mimics of β-lactamantibiotics

AU - Hadfield, Peter S.

AU - Casey, Lorraine A.

AU - Galt, Ronald H.B.

AU - Vilanova, Bartholomew

AU - Page, Michael I.

PY - 2002/12

Y1 - 2002/12

N2 - Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the β-lactam antibiotics and their chemical and biological reactivity determined.

AB - Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the β-lactam antibiotics and their chemical and biological reactivity determined.

KW - β-lactamase

KW - γ-lactams

KW - Antibacterials

KW - Hydrolysis

KW - Imides

KW - Isatins

UR - http://www.scopus.com/inward/record.url?scp=3242790999&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:3242790999

VL - 2002

SP - 125

EP - 144

JO - Arkivoc

JF - Arkivoc

SN - 1551-7004

IS - 6

ER -

Imide and isatin derivatives as γ-lactam mimics of β-lactamantibiotics

Abstract

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