TY - JOUR
T1 - Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia
AU - Olajide, Olumayokun
AU - Iwuanyanwu, Victoria
AU - Banjo, Owolabi
AU - Kato, Atsushi
AU - Penkova, Yana
AU - Fleet, George
AU - Nash, PhytoQuest
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/23
Y1 - 2022/5/23
N2 - Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer’s disease. (2) Methods. A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses. (3) Results. A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found. (4) Conclusions. Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.
AB - Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer’s disease. (2) Methods. A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses. (3) Results. A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found. (4) Conclusions. Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.
KW - (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid
KW - iminosugar amino acid idoBR1
KW - Cucumis sativus
KW - microglia cell line
KW - lipopolysaccharide
KW - pro-inflammatory factors
KW - neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=85130553852&partnerID=8YFLogxK
U2 - 10.3390/molecules27103342
DO - 10.3390/molecules27103342
M3 - Article
VL - 27
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 10
M1 - 3342
ER -
