Impact of an enhanced antibiotic stewardship on reducing methicillin-resistant Staphylococcus aureus in primary and secondary healthcare settings

M. A. Aldeyab, M. G. Scott, M. P. Kearney, Y. M. Alahmadi, F. A. Magee, G. Conlon, J. C. McElnay

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The objective of this study was to evaluate the impact of restricting high-risk antibiotics on methicillin-resistant Staphylococcus aureus (MRSA) incidence rates in a hospital setting. A secondary objective was to assess the impact of reducing fluoroquinolone use in the primary-care setting on MRSA incidence in the community. This was an interventional, retrospective, ecological investigation in both hospital and community (January 2006 to June 2010). Segmented regression analysis of interrupted time-series was employed to evaluate the intervention. The restriction of high-risk antibiotics was associated with a significant change in hospital MRSA incidence trend (coefficient=-0·00561, P=0·0057). Analysis showed that the intervention relating to reducing fluoroquinolone use in the community was associated with a significant trend change in MRSA incidence in community (coefficient=-0·00004, P=0·0299). The reduction in high-risk antibiotic use and fluoroquinolone use contributed to both a reduction in incidence rates of MRSA in hospital and community (primary-care) settings.

Original languageEnglish
Pages (from-to)494-500
Number of pages7
JournalEpidemiology and Infection
Volume142
Issue number3
Early online date5 Jun 2013
DOIs
Publication statusPublished - 1 Mar 2014
Externally publishedYes

Fingerprint

Dive into the research topics of 'Impact of an enhanced antibiotic stewardship on reducing methicillin-resistant Staphylococcus aureus in primary and secondary healthcare settings'. Together they form a unique fingerprint.

Cite this