In Search of Geographical Patterns in European Mitochondrial DNA

Martin Richards, Vincent Macaulay, Antonio Torroni, Hans Jürgen Bandelt

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Previous studies of mitochondrial DNA (mtDNA) in Europe and the Near East have suggested that, in contrast with classical markers and the Y chromosome, mtDNA does not exhibit significant geographical structuring. Here, we show that, with a sufficiently large sample size and a better resolved mtDNA tree, clades of mtDNA do indeed exhibit gradients similar to those of other marker systems. However, the more detailed analyses afforded by molecular sequence data suggest that the explanations for these gradients are likely to be much more complex than those proposed for classical markers.

LanguageEnglish
Pages1168-1174
Number of pages7
JournalAmerican Journal of Human Genetics
Volume71
Issue number5
Early online date25 Sep 2002
DOIs
Publication statusPublished - Nov 2002

Fingerprint

Mitochondrial DNA
Molecular Sequence Data
Middle East
Y Chromosome
Sample Size

Cite this

Richards, Martin ; Macaulay, Vincent ; Torroni, Antonio ; Bandelt, Hans Jürgen. / In Search of Geographical Patterns in European Mitochondrial DNA. In: American Journal of Human Genetics. 2002 ; Vol. 71, No. 5. pp. 1168-1174.
@article{c67d8cb5f7324178ae842ded95aa4189,
title = "In Search of Geographical Patterns in European Mitochondrial DNA",
abstract = "Previous studies of mitochondrial DNA (mtDNA) in Europe and the Near East have suggested that, in contrast with classical markers and the Y chromosome, mtDNA does not exhibit significant geographical structuring. Here, we show that, with a sufficiently large sample size and a better resolved mtDNA tree, clades of mtDNA do indeed exhibit gradients similar to those of other marker systems. However, the more detailed analyses afforded by molecular sequence data suggest that the explanations for these gradients are likely to be much more complex than those proposed for classical markers.",
author = "Martin Richards and Vincent Macaulay and Antonio Torroni and Bandelt, {Hans J{\"u}rgen}",
year = "2002",
month = "11",
doi = "10.1086/342930",
language = "English",
volume = "71",
pages = "1168--1174",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "5",

}

In Search of Geographical Patterns in European Mitochondrial DNA. / Richards, Martin; Macaulay, Vincent; Torroni, Antonio; Bandelt, Hans Jürgen.

In: American Journal of Human Genetics, Vol. 71, No. 5, 11.2002, p. 1168-1174.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In Search of Geographical Patterns in European Mitochondrial DNA

AU - Richards, Martin

AU - Macaulay, Vincent

AU - Torroni, Antonio

AU - Bandelt, Hans Jürgen

PY - 2002/11

Y1 - 2002/11

N2 - Previous studies of mitochondrial DNA (mtDNA) in Europe and the Near East have suggested that, in contrast with classical markers and the Y chromosome, mtDNA does not exhibit significant geographical structuring. Here, we show that, with a sufficiently large sample size and a better resolved mtDNA tree, clades of mtDNA do indeed exhibit gradients similar to those of other marker systems. However, the more detailed analyses afforded by molecular sequence data suggest that the explanations for these gradients are likely to be much more complex than those proposed for classical markers.

AB - Previous studies of mitochondrial DNA (mtDNA) in Europe and the Near East have suggested that, in contrast with classical markers and the Y chromosome, mtDNA does not exhibit significant geographical structuring. Here, we show that, with a sufficiently large sample size and a better resolved mtDNA tree, clades of mtDNA do indeed exhibit gradients similar to those of other marker systems. However, the more detailed analyses afforded by molecular sequence data suggest that the explanations for these gradients are likely to be much more complex than those proposed for classical markers.

UR - http://www.scopus.com/inward/record.url?scp=0036842650&partnerID=8YFLogxK

U2 - 10.1086/342930

DO - 10.1086/342930

M3 - Article

VL - 71

SP - 1168

EP - 1174

JO - American Journal of Human Genetics

T2 - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 5

ER -