In-situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals

Research output: Contribution to journalArticle

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Abstract

The present study aimed to develop and validate an advanced image stitching algorithm integrated with chemical imaging at the nanometre scale. This was applied to track the swelling, erosion, drug release and changes in surface texture of a swelling-controlled release system. The technique involves the delivery and withdrawal of a liquid droplet from the surface of the tablet alongside capturing multiple images of tablet surface using white light profilometry. The recovered liquid was then subject to chemical analysis for the quantification of drug and HPMC. The multiple images acquired during drug release were stitched together using an algorithm developed to generate a full tablet surface. New methods for swelling analysis (regional point, area and multiple regional analysis techniques) were also successfully developed. The results exhibited the exceptional capability of this technique for providing quantitative information regarding swelling, erosion, drug release and surface topography, hence negating the need for separate investigations. Moreover, it can also be anticipated that this technique may have potential use in other fields where surface dissolution, erosion and swelling have significant impact.
LanguageEnglish
Pages16119-16129
Number of pages11
JournalRSC Advances
Volume9
Issue number28
Early online date30 May 2019
DOIs
Publication statusPublished - 1 Jun 2019

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Drug products
Swelling
Imaging techniques
Tablets
Erosion
Pharmaceutical Preparations
Profilometry
Liquids
Surface topography
Dissolution
Textures
Chemical analysis

Cite this

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abstract = "The present study aimed to develop and validate an advanced image stitching algorithm integrated with chemical imaging at the nanometre scale. This was applied to track the swelling, erosion, drug release and changes in surface texture of a swelling-controlled release system. The technique involves the delivery and withdrawal of a liquid droplet from the surface of the tablet alongside capturing multiple images of tablet surface using white light profilometry. The recovered liquid was then subject to chemical analysis for the quantification of drug and HPMC. The multiple images acquired during drug release were stitched together using an algorithm developed to generate a full tablet surface. New methods for swelling analysis (regional point, area and multiple regional analysis techniques) were also successfully developed. The results exhibited the exceptional capability of this technique for providing quantitative information regarding swelling, erosion, drug release and surface topography, hence negating the need for separate investigations. Moreover, it can also be anticipated that this technique may have potential use in other fields where surface dissolution, erosion and swelling have significant impact.",
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In-situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals. / Nirwan, Jorabar; Conway, Barbara; Ghori, Muhammad Usman .

In: RSC Advances, Vol. 9, No. 28, 01.06.2019, p. 16119-16129.

Research output: Contribution to journalArticle

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