In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety

Lathewdeipor Shadap; Venkanna Banothu; Emma Pinder; Roger Phillips; Werner Kaminsky; Mohan Rao Kollipara

doi:10.1080/00958972.2020.1777547

In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety

Lathewdeipor Shadap, Venkanna Banothu, Emma Pinder, Roger Phillips, Werner Kaminsky, Mohan Rao Kollipara

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Ligands containing benzothiazole moiety upon reaction with arene platinum group metal precursors in dry methanol yielded cationic complexes 1–9 having N∩N bonding mode. The general formulation of the complexes is presented as [(arene)M(κ ² _N∩N-L)Cl] ⁺, where L = L1, L2 and L3, M = Ru, Rh and Ir, and arene = p-cymene and pentamethylcyclopentadiene (Cp*). All these complexes were characterized by various spectroscopic techniques and were found to be air-stable. The biological activity studies of these complexes and ligands such as antibacterial and cytotoxicity studies showed that complexes 5, 6 and 9 have the highest antibacterial activity and ligand L1 has the highest cytotoxicity activity.

Original language	English
Pages (from-to)	1538-1553
Number of pages	16
Journal	Journal of Coordination Chemistry
Volume	73
Issue number	10
Early online date	12 Jun 2020
DOIs	https://doi.org/10.1080/00958972.2020.1777547
Publication status	Published - 12 Jun 2020

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title = "In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety",

abstract = "Ligands containing benzothiazole moiety upon reaction with arene platinum group metal precursors in dry methanol yielded cationic complexes 1–9 having N∩N bonding mode. The general formulation of the complexes is presented as [(arene)M(κ 2 N∩N-L)Cl] +, where L = L1, L2 and L3, M = Ru, Rh and Ir, and arene = p-cymene and pentamethylcyclopentadiene (Cp*). All these complexes were characterized by various spectroscopic techniques and were found to be air-stable. The biological activity studies of these complexes and ligands such as antibacterial and cytotoxicity studies showed that complexes 5, 6 and 9 have the highest antibacterial activity and ligand L1 has the highest cytotoxicity activity. ",

keywords = "Ruthenium, Rhodium, Iridium, Antibacterial, Cytotoxicity, iridium, antibacterial, cytotoxicity, rhodium",

author = "Lathewdeipor Shadap and Venkanna Banothu and Emma Pinder and Roger Phillips and Werner Kaminsky and Kollipara, {Mohan Rao}",

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doi = "10.1080/00958972.2020.1777547",

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T1 - In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety

AU - Shadap, Lathewdeipor

AU - Banothu, Venkanna

AU - Pinder, Emma

AU - Phillips, Roger

AU - Kaminsky, Werner

AU - Kollipara, Mohan Rao

PY - 2020/6/12

Y1 - 2020/6/12

N2 - Ligands containing benzothiazole moiety upon reaction with arene platinum group metal precursors in dry methanol yielded cationic complexes 1–9 having N∩N bonding mode. The general formulation of the complexes is presented as [(arene)M(κ 2 N∩N-L)Cl] +, where L = L1, L2 and L3, M = Ru, Rh and Ir, and arene = p-cymene and pentamethylcyclopentadiene (Cp*). All these complexes were characterized by various spectroscopic techniques and were found to be air-stable. The biological activity studies of these complexes and ligands such as antibacterial and cytotoxicity studies showed that complexes 5, 6 and 9 have the highest antibacterial activity and ligand L1 has the highest cytotoxicity activity.

AB - Ligands containing benzothiazole moiety upon reaction with arene platinum group metal precursors in dry methanol yielded cationic complexes 1–9 having N∩N bonding mode. The general formulation of the complexes is presented as [(arene)M(κ 2 N∩N-L)Cl] +, where L = L1, L2 and L3, M = Ru, Rh and Ir, and arene = p-cymene and pentamethylcyclopentadiene (Cp*). All these complexes were characterized by various spectroscopic techniques and were found to be air-stable. The biological activity studies of these complexes and ligands such as antibacterial and cytotoxicity studies showed that complexes 5, 6 and 9 have the highest antibacterial activity and ligand L1 has the highest cytotoxicity activity.

KW - Ruthenium

KW - Rhodium

KW - Iridium

KW - Antibacterial

KW - Cytotoxicity

KW - iridium

KW - antibacterial

KW - cytotoxicity

KW - rhodium

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DO - 10.1080/00958972.2020.1777547

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EP - 1553

JO - Journal of Coordination Chemistry

JF - Journal of Coordination Chemistry

SN - 0095-8972

IS - 10

ER -

In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety

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