In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety

Lathewdeipor Shadap, Venkanna Banothu, Emma Pinder, Roger Phillips, Werner Kaminsky, Mohan Rao Kollipara

Research output: Contribution to journalArticle

Abstract

Ligands containing benzothiazole moiety upon reaction with arene platinum group metal precursors in dry methanol yielded cationic complexes 1-9 having N∩N bonding mode. The general formulation of the complexes is presented as [(arene)M(2N∩N-L)Cl]+ where, L = L1, L2 and L3, M = Ru, Rh and Ir, and arene = p-cymene and pentamethylcyclopentadiene (Cp*). All these complexes were characterized by various spectroscopic techniques and were found to be air-stable. The biological activity studies of these complexes and ligands such as antibacterial and cytotoxicity studies showed that complexes 5, 6 and 9 have the highest antibacterial activity and ligand L1 has the highest cytotoxicity activity.
Original languageEnglish
JournalJournal of Coordination Chemistry
Early online date12 Jun 2020
DOIs
Publication statusE-pub ahead of print - 12 Jun 2020

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