TY - JOUR
T1 - Increased Oxidative Stress as a Risk Factor in Chronic Idiopathic Axonal Polyneuropathy
AU - Zis, Panagiotis
AU - Mchugh, Patrick C.
AU - Manca, Maurizio
AU - Sarrigiannis, Ptolemaios Georgios
AU - Rao, Dasappaiah Ganesh
AU - Hadjivassiliou, Marios
PY - 2018/12
Y1 - 2018/12
N2 - Chronic idiopathic axonal polyneuropathy (CIAP) is a disorder with insidious onset and slow progression, where no etiology is identified despite appropriate investigations. We aimed to investigate the role of oxidative stress as a risk factor for the pathogenesis of CIAP. Sera of patients with CIAP were tested for protein carbonyl (PC) and 8-hydroxydeoxyguanosine (8H). As a control group, we recruited patients with gluten neuropathy. Twenty-one patients with CIAP and 21 controls were recruited. The two groups did not differ significantly regarding demographics or clinical characteristics (i.e., neuropathy type or disease severity). After adjusting for gender, having CIAP was positively correlated with both the 8H titer (standardized beta coefficient 0.349, p = 0.013) and the PC titer (standardized beta coefficient 0.469, p = 0.001). Oxidative stress appears to be increased in CIAP and might have a role in the pathogenesis of the disease.
AB - Chronic idiopathic axonal polyneuropathy (CIAP) is a disorder with insidious onset and slow progression, where no etiology is identified despite appropriate investigations. We aimed to investigate the role of oxidative stress as a risk factor for the pathogenesis of CIAP. Sera of patients with CIAP were tested for protein carbonyl (PC) and 8-hydroxydeoxyguanosine (8H). As a control group, we recruited patients with gluten neuropathy. Twenty-one patients with CIAP and 21 controls were recruited. The two groups did not differ significantly regarding demographics or clinical characteristics (i.e., neuropathy type or disease severity). After adjusting for gender, having CIAP was positively correlated with both the 8H titer (standardized beta coefficient 0.349, p = 0.013) and the PC titer (standardized beta coefficient 0.469, p = 0.001). Oxidative stress appears to be increased in CIAP and might have a role in the pathogenesis of the disease.
KW - Chronic idiopathic axonal polyneuropathy
KW - CIAP
KW - Gluten neuropathy
KW - Pathogenesis
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85055721212&partnerID=8YFLogxK
U2 - 10.1007/s12031-018-1200-5
DO - 10.1007/s12031-018-1200-5
M3 - Article
VL - 66
SP - 547
EP - 551
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
SN - 0895-8696
IS - 4
ER -