Influence of Polymer Ratio and Surfactants on Controlled Drug Release from Cellulosic Microsponges

Yasser Shahzad; Sidra Saeed; Muhammad Ghori; Tariq Mahmood; Mehmood Yousaf; Muhammad Jamshaid; Rizwan Sheikh; Syed A. A. Rizvi

doi:10.1016/j.ijbiomac.2017.11.089

Influence of Polymer Ratio and Surfactants on Controlled Drug Release from Cellulosic Microsponges

Yasser Shahzad, Sidra Saeed, Muhammad Ghori, Tariq Mahmood, Mehmood Yousaf, Muhammad Jamshaid, Rizwan Sheikh, Syed A. A. Rizvi

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic (hydroxypropyl methylcellulose) polymers mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised. Our results, for the first time, indicate successful and optimised formulation with desired pharmaceutical characteristics using a combination of hydrophobic and hydrophilic polymers.

Original language	English
Pages (from-to)	963-970
Number of pages	8
Journal	International Journal of Biological Macromolecules
Volume	109
Early online date	14 Nov 2017
DOIs	https://doi.org/10.1016/j.ijbiomac.2017.11.089
Publication status	Published - Apr 2018

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http://eprints.hud.ac.uk/id/eprint/33872Licence: CC BY-NC-ND

Cite this

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title = "Influence of Polymer Ratio and Surfactants on Controlled Drug Release from Cellulosic Microsponges",

abstract = "Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic (hydroxypropyl methylcellulose) polymers mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised. Our results, for the first time, indicate successful and optimised formulation with desired pharmaceutical characteristics using a combination of hydrophobic and hydrophilic polymers.",

keywords = "Controlled release, Ethyl cellulose, Hydroxypropyl methylcellulose, Microsponges, Porosity, Surfactants",

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language = "English",

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T1 - Influence of Polymer Ratio and Surfactants on Controlled Drug Release from Cellulosic Microsponges

AU - Shahzad, Yasser

AU - Saeed, Sidra

AU - Ghori, Muhammad

AU - Mahmood, Tariq

AU - Yousaf, Mehmood

AU - Jamshaid, Muhammad

AU - Sheikh, Rizwan

AU - Rizvi, Syed A. A.

PY - 2018/4

Y1 - 2018/4

N2 - Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic (hydroxypropyl methylcellulose) polymers mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised. Our results, for the first time, indicate successful and optimised formulation with desired pharmaceutical characteristics using a combination of hydrophobic and hydrophilic polymers.

AB - Microsponge refers to a highly cross-linked particle system with a capacity to adsorb (like a dry sponge) pharmaceutical materials. There are various methods available to prepare microsponge formulations, in this study we used quasi emulsion-solvent diffusion method with a combination of hydrophobic (ethyl cellulose) and hydrophilic (hydroxypropyl methylcellulose) polymers mediated via Tween 80 and polyvinyl alcohol. Various ratios and amounts of the polymers and surfactants were used to prepare microsponge formulations using ketoprofen as a model drug and extensively characterised. Our results, for the first time, indicate successful and optimised formulation with desired pharmaceutical characteristics using a combination of hydrophobic and hydrophilic polymers.

KW - Controlled release

KW - Ethyl cellulose

KW - Hydroxypropyl methylcellulose

KW - Microsponges

KW - Porosity

KW - Surfactants

UR - https://www.journals.elsevier.com/international-journal-of-biological-macromolecules

UR - http://www.scopus.com/inward/record.url?scp=85034436163&partnerID=8YFLogxK

U2 - 10.1016/j.ijbiomac.2017.11.089

DO - 10.1016/j.ijbiomac.2017.11.089

M3 - Article

VL - 109

SP - 963

EP - 970

JO - Energy Economics

JF - Energy Economics

SN - 0141-8130

ER -

Influence of Polymer Ratio and Surfactants on Controlled Drug Release from Cellulosic Microsponges

Abstract

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