Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism

Keyphrases

• Biflavonoids 100%
• Neuroinflammation 100%
• Kolaviron 100%
• Nrf2-ARE 100%
• Antioxidant 100%
• Protective Mechanism 100%
• BV2 Microglia 100%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 30%
• Lipopolysaccharide 23%
• RNA Interference 15%
• Inflammatory Cytokines 15%
• NF-B 15%
• Prostaglandin E2 15%
• Anti-inflammatory Effect 15%
• Reactive Oxygen Species 15%
• Cyclooxygenase-2 15%
• Inducible Nitric Oxide Synthase 15%
• Mechanistic Studies 7%
• Immunoblotting 7%
• Protein Level 7%
• Molecular Mechanism 7%
• Signaling Pathway 7%
• Pharmacological Activities 7%
• Neuroprotective Effect 7%
• Microglia 7%
• Edible Seeds 7%
• West African 7%
• Nrf2-ARE Signaling Pathway 7%
• Antioxidant Response Element 7%
• HT22 7%
• Binding Assay 7%
• Interleukin-6 7%
• Garcinia Kola 7%
• Heme oxygenase-1 (HO-1) 7%
• Neurodegenerative Diseases 7%
• Antioxidant Effect 7%
• HT22 Neurons 7%
• Induced Toxicity 7%
• Reporter Assay 7%
• Nitric Oxide 7%
• Hippocampal Neurons 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Antioxidant 100%
• Nervous System Inflammation 100%
• Transcription Factor Nrf2 100%
• Biflavonoid 100%
• Kolaviron 100%
• Lipopolysaccharide 23%
• Antiinflammatory Activity 15%
• Cytokine 15%
• Prostaglandin E2 15%
• Inducible Nitric Oxide Synthase 15%
• Reactive Oxygen Metabolite 15%
• Western Blot 7%
• Pharmacological Activity 7%
• Nitric Oxide 7%
• Neuroprotective Agent 7%
• Interleukin 6 7%
• Tumor Necrosis Factor 7%
• Garcinia Kola 7%
• Cyclooxygenase 2 7%