Interactions of cells with elastic cholesteryl liquid crystals

C. F. Soon, M. Youseffi, N. Blagden, S. B. Lobo, F. A. Javid, M. C T Denyer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Citations (Scopus)


Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s-1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationBiomaterials, Cellular and Tissue Engineering, Artificial Organs
Number of pages4
Publication statusPublished - 1 Dec 2009
EventWorld Congress on Medical Physics and Biomedical Engineering : Biomaterials, Cellular and Tissue Engineering & Artificial Organs - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings


ConferenceWorld Congress on Medical Physics and Biomedical Engineering

Fingerprint Dive into the research topics of 'Interactions of cells with elastic cholesteryl liquid crystals'. Together they form a unique fingerprint.

Cite this