Interactions of cells with elastic cholesteryl liquid crystals

C. F. Soon, M. Youseffi, N. Blagden, S. B. Lobo, F. A. Javid, M. C T Denyer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s-1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationBiomaterials, Cellular and Tissue Engineering, Artificial Organs
Pages9-12
Number of pages4
Volume25
Edition10
DOIs
Publication statusPublished - 1 Dec 2009
EventWorld Congress on Medical Physics and Biomedical Engineering : Biomaterials, Cellular and Tissue Engineering & Artificial Organs - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings
PublisherSpringer
Number10
Volume25

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering
CountryGermany
CityMunich
Period7/09/0912/09/09

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  • Cite this

    Soon, C. F., Youseffi, M., Blagden, N., Lobo, S. B., Javid, F. A., & Denyer, M. C. T. (2009). Interactions of cells with elastic cholesteryl liquid crystals. In World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs (10 ed., Vol. 25, pp. 9-12). (IFMBE Proceedings; Vol. 25, No. 10). https://doi.org/10.1007/978-3-642-03900-3_4