Interactions of cells with elastic cholesteryl liquid crystals

C. F. Soon; M. Youseffi; N. Blagden; S. B. Lobo; F. A. Javid; M. C T Denyer

doi:10.1007/978-3-642-03900-3_4

Interactions of cells with elastic cholesteryl liquid crystals

C. F. Soon, M. Youseffi, N. Blagden, S. B. Lobo, F. A. Javid, M. C T Denyer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Citations (Scopus)

Abstract

Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s^-1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering
Subtitle of host publication	Biomaterials, Cellular and Tissue Engineering, Artificial Organs
Editors	Olaf Dössel, Wolfgang C. Schlegel
Pages	9-12
Number of pages	4
Volume	25
Edition	10
DOIs	https://doi.org/10.1007/978-3-642-03900-3_4
Publication status	Published - 1 Dec 2009
Event	World Congress on Medical Physics and Biomedical Engineering : Biomaterials, Cellular and Tissue Engineering & Artificial Organs - Munich, Germany Duration: 7 Sept 2009 → 12 Sept 2009

Publication series

Name	IFMBE Proceedings
Publisher	Springer
Number	10
Volume	25

Conference

Conference	World Congress on Medical Physics and Biomedical Engineering
Country/Territory	Germany
City	Munich
Period	7/09/09 → 12/09/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-3-642-03900-3_4Licence: Unspecified

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Soon, C. F., Youseffi, M., Blagden, N., Lobo, S. B., Javid, F. A., & Denyer, M. C. T. (2009). Interactions of cells with elastic cholesteryl liquid crystals. In O. Dössel, & W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs (10 ed., Vol. 25, pp. 9-12). (IFMBE Proceedings; Vol. 25, No. 10). https://doi.org/10.1007/978-3-642-03900-3_4

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title = "Interactions of cells with elastic cholesteryl liquid crystals",

abstract = "Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s-1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.",

keywords = "Cell adhesion, Cell mechanic, Human keratinocytes, Liquid Crystals",

author = "Soon, \{C. F.\} and M. Youseffi and N. Blagden and Lobo, \{S. B.\} and Javid, \{F. A.\} and Denyer, \{M. C T\}",

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doi = "10.1007/978-3-642-03900-3\_4",

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booktitle = "World Congress on Medical Physics and Biomedical Engineering",

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Soon, CF, Youseffi, M, Blagden, N, Lobo, SB, Javid, FA & Denyer, MCT 2009, Interactions of cells with elastic cholesteryl liquid crystals. in O Dössel & WC Schlegel (eds), World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs. 10 edn, vol. 25, IFMBE Proceedings, no. 10, vol. 25, pp. 9-12, World Congress on Medical Physics and Biomedical Engineering , Munich, Bavaria, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03900-3_4

Interactions of cells with elastic cholesteryl liquid crystals. / Soon, C. F.; Youseffi, M.; Blagden, N. et al.
World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs. ed. / Olaf Dössel; Wolfgang C. Schlegel. Vol. 25 10. ed. 2009. p. 9-12 (IFMBE Proceedings; Vol. 25, No. 10).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Interactions of cells with elastic cholesteryl liquid crystals

AU - Soon, C. F.

AU - Youseffi, M.

AU - Blagden, N.

AU - Lobo, S. B.

AU - Javid, F. A.

AU - Denyer, M. C T

PY - 2009/12/1

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N2 - Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s-1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.

AB - Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s-1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.

KW - Cell adhesion

KW - Cell mechanic

KW - Human keratinocytes

KW - Liquid Crystals

UR - https://www.scopus.com/pages/publications/77950161519

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BT - World Congress on Medical Physics and Biomedical Engineering

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Soon CF, Youseffi M, Blagden N, Lobo SB, Javid FA, Denyer MCT. Interactions of cells with elastic cholesteryl liquid crystals. In Dössel O, Schlegel WC, editors, World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs. 10 ed. Vol. 25. 2009. p. 9-12. (IFMBE Proceedings; 10). doi: 10.1007/978-3-642-03900-3_4

Interactions of cells with elastic cholesteryl liquid crystals

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