To understand the effects of vibration of cylinder liners on engine combustion performance, tribological behaviour and vibro-acoustic radiations, this study investigates the dynamic responses of cylinder liners by finite-element modelling and experimental validation. The finite-element model is established in this study to predict the dynamic responses of cylinder liners to two significant sources: combustion shock and piston side thrust. It takes into account both the characteristics of structural modes and nonlinearities of assembly constraints when selecting adequate elements for efficient computation of the responses under both the highly nonlinear combustion pressure excitations and subsequent piston slap impacts. The predictions are then evaluated against experimental results under different engine operating conditions. To suppressing noise in measured signals, continuous wavelet analysis is employed to process the complicated responses for characterizing key response events and their frequency ranges. The results show agreeable correspondences between the numerical predictions and measured vibration signals, paving the way for investigating its effect on the combustion and lubrication processes.