Investigation of polarization-sensitive optical coherence tomography towards the study of microstructure of articular cartilage

Deepa Kasaragod, Zenghai Lu, Christine Le Maitre, J. Mark Wilkinson, Stephen Matcher

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper highlights the extended Jones matrix calculus based multi-angle study carried out to understand the depth dependent structural orientation of the collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography (PS-OCT). A 3D lamellar model for the collagen fiber orientation, with a quadratic profile for the arching of the collagen fibers in transitional zone which points towards an ordered arrangement of fibers in that zone is the basis of the organization architecture of collagen fibers in articular cartilage. Experimental data for both ex-vivo bovine fetlock and human patellar cartilage samples are compared with theoretical predictions, with a good quantitative agreement for bovine and a reasonable qualitative agreement for human articular cartilage samples being obtained.

Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
EditorsJames G. Fujimoto, Joseph A. Izatt, Valery V. Tuchin
PublisherSPIE
Number of pages6
Volume8571
ISBN (Print)9780819493408
DOIs
Publication statusPublished - 20 Mar 2013
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII - San Francisco, United States
Duration: 2 Feb 20137 Feb 2013
Conference number: 17

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8571
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
Country/TerritoryUnited States
CitySan Francisco
Period2/02/137/02/13

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